Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis

Abstract Although patients with diabetes mellitus mostly present with enlarged or normal-sized kidneys throughout their life, a small proportion of patients have small kidneys. This longitudinal study enrolled 83 diabetic patients treated with peritoneal dialysis (PD) between 2015 and 2019. Patients...

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Autores principales:	Chun-Hao Chen, Chao-Yu Chen, Mei-Ching Yu, Jen-Fen Fu, Yi-Chou Hou, I.-Kuan Wang, Yu-Hsin Chih, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu, Frederick W. K. Tam, Tzung-Hai Yen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffc5b656eb3a441383d097004e4d4d38
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spelling	oai:doaj.org-article:ffc5b656eb3a441383d097004e4d4d382021-12-02T15:51:12ZImpact of kidney size on mortality in diabetic patients receiving peritoneal dialysis10.1038/s41598-021-87684-z2045-2322https://doaj.org/article/ffc5b656eb3a441383d097004e4d4d382021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87684-zhttps://doaj.org/toc/2045-2322Abstract Although patients with diabetes mellitus mostly present with enlarged or normal-sized kidneys throughout their life, a small proportion of patients have small kidneys. This longitudinal study enrolled 83 diabetic patients treated with peritoneal dialysis (PD) between 2015 and 2019. Patients were stratified into two groups, those with enlarged or normal (n = 67) or small (n = 16) kidneys, based on their kidney sizes before dialysis. Patients with small kidney size were not only older (76.63 ± 10.63 vs. 68.03 ± 11.26 years, P = 0.007), suffered longer duration of diabetes mellitus (272.09 ± 305.09 vs. 151.44 ± 85.31 month, P = 0.006) and predominantly female (75.0 vs. 41.8%, P = 0.017), but also had lower serum levels of creatinine (9.63 ± 2.82 vs. 11.74 ± 3.32 mg/dL, P = 0.022) and albumin (3.23 ± 0.67 vs. 3.60 ± 0.47 g/dL, P = 0.010) than patients with enlarged or normal kidney size. At the end of analysis, 14 (16.9%) patients died. Patients with small kidney size demonstrated higher all-cause (50.0 vs. 9.0%, P < 0.001) and infection-related (43.8 vs. 7.5%, P < 0.001) mortality than patients with enlarged or normal kidney size. In a multivariate-logistic-regression model, small kidney size was a powerful predictor of mortality (odds ratio 6.452, 95% confidence interval 1.220–34.482, P = 0.028). Diabetic patients with small kidney size at the beginning of PD carry a substantial risk for mortality.Chun-Hao ChenChao-Yu ChenMei-Ching YuJen-Fen FuYi-Chou HouI.-Kuan WangYu-Hsin ChihCheng-Hao WengWen-Hung HuangChing-Wei HsuFrederick W. K. TamTzung-Hai YenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun-Hao Chen Chao-Yu Chen Mei-Ching Yu Jen-Fen Fu Yi-Chou Hou I.-Kuan Wang Yu-Hsin Chih Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Frederick W. K. Tam Tzung-Hai Yen Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
description	Abstract Although patients with diabetes mellitus mostly present with enlarged or normal-sized kidneys throughout their life, a small proportion of patients have small kidneys. This longitudinal study enrolled 83 diabetic patients treated with peritoneal dialysis (PD) between 2015 and 2019. Patients were stratified into two groups, those with enlarged or normal (n = 67) or small (n = 16) kidneys, based on their kidney sizes before dialysis. Patients with small kidney size were not only older (76.63 ± 10.63 vs. 68.03 ± 11.26 years, P = 0.007), suffered longer duration of diabetes mellitus (272.09 ± 305.09 vs. 151.44 ± 85.31 month, P = 0.006) and predominantly female (75.0 vs. 41.8%, P = 0.017), but also had lower serum levels of creatinine (9.63 ± 2.82 vs. 11.74 ± 3.32 mg/dL, P = 0.022) and albumin (3.23 ± 0.67 vs. 3.60 ± 0.47 g/dL, P = 0.010) than patients with enlarged or normal kidney size. At the end of analysis, 14 (16.9%) patients died. Patients with small kidney size demonstrated higher all-cause (50.0 vs. 9.0%, P < 0.001) and infection-related (43.8 vs. 7.5%, P < 0.001) mortality than patients with enlarged or normal kidney size. In a multivariate-logistic-regression model, small kidney size was a powerful predictor of mortality (odds ratio 6.452, 95% confidence interval 1.220–34.482, P = 0.028). Diabetic patients with small kidney size at the beginning of PD carry a substantial risk for mortality.
format	article
author	Chun-Hao Chen Chao-Yu Chen Mei-Ching Yu Jen-Fen Fu Yi-Chou Hou I.-Kuan Wang Yu-Hsin Chih Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Frederick W. K. Tam Tzung-Hai Yen
author_facet	Chun-Hao Chen Chao-Yu Chen Mei-Ching Yu Jen-Fen Fu Yi-Chou Hou I.-Kuan Wang Yu-Hsin Chih Cheng-Hao Weng Wen-Hung Huang Ching-Wei Hsu Frederick W. K. Tam Tzung-Hai Yen
author_sort	Chun-Hao Chen
title	Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
title_short	Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
title_full	Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
title_fullStr	Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
title_full_unstemmed	Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
title_sort	impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffc5b656eb3a441383d097004e4d4d38
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Impact of kidney size on mortality in diabetic patients receiving peritoneal dialysis

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