Evaluation of bisphenylthiazoles as a promising class for combating multidrug-resistant fungal infections.

To minimize the intrinsic toxicity of the antibacterial agent hydrazinyloxadiazole 1, the hydrazine moiety was replaced with ethylenediamine (compound 7). This replacement generated a potent antifungal agent with no antibacterial activity. Notably, use of a 1,2-diaminocyclohexane moiety, as a confor...

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Autores principales: Mohamed Hagras, Nader S Abutaleb, Ahmed M Sayed, Ehab A Salama, Mohamed N Seleem, Abdelrahman S Mayhoub
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/ffc5e06893d34d8db43eed9dd9983c27
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