Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research

Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative disease. The physio-pat...

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Autores principales:	Dallece E. Curley, Ashley E. Webb, Douglas J. Sheffler, Carolina L. Haass-Koffler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CRFBP AUD stress neurodegeneration HPA axis aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ffc762c6607344c09d06fbe13927e788
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spelling	oai:doaj.org-article:ffc762c6607344c09d06fbe13927e7882021-12-01T13:20:30ZCorticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research1662-515310.3389/fnbeh.2021.786855https://doaj.org/article/ffc762c6607344c09d06fbe13927e7882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.786855/fullhttps://doaj.org/toc/1662-5153Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative disease. The physio-pathology of stress is regulated by the corticotropin-releasing factor (CRF) system, the upstream component of the hypothalamic-pituitary-adrenal (HPA) axis. Extensive literature has shown that dysregulation of the CRF neuroendocrine system contributes to escalation of alcohol consumption and, similarly, chronic alcohol consumption contributes to disruption of the stress system. The CRF system also represents the central switchboard for regulating homeostasis, and more recent studies have found that stress and aberrations in the CRF pathway are implicated in accelerated aging and age-related neurodegenerative disease. Corticotropin releasing factor binding protein (CRFBP) is a secreted glycoprotein distributed in peripheral tissues and in specific brain regions. It neutralizes the effects of CRF by sequestering free CRF, but may also possess excitatory function by interacting with CRF receptors. CRFBP’s dual role in influencing CRF bioavailability and CRF receptor signaling has been shown to have a major part in the HPA axis response. Therefore, CRFBP may represent a valuable target to treat stress-related illness, including: development of novel medications to treat AUD and restore homeostasis in the aging brain. This narrative review focuses on molecular mechanisms related to the role of CRFBP in the progression of addictive and psychiatric disorders, biological aging, and age-related neurodegenerative disease. We provide an overview of recent studies investigating modulation of this pathway as a potential therapeutic target for AUD and age-related neurodegenerative disease.Dallece E. CurleyDallece E. CurleyAshley E. WebbAshley E. WebbDouglas J. ShefflerDouglas J. ShefflerCarolina L. Haass-KofflerCarolina L. Haass-KofflerCarolina L. Haass-KofflerCarolina L. Haass-KofflerFrontiers Media S.A.articleCRFBPAUDstressneurodegenerationHPA axisagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CRFBP AUD stress neurodegeneration HPA axis aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	CRFBP AUD stress neurodegeneration HPA axis aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Dallece E. Curley Dallece E. Curley Ashley E. Webb Ashley E. Webb Douglas J. Sheffler Douglas J. Sheffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
description	Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age-related neurodegenerative disease. The physio-pathology of stress is regulated by the corticotropin-releasing factor (CRF) system, the upstream component of the hypothalamic-pituitary-adrenal (HPA) axis. Extensive literature has shown that dysregulation of the CRF neuroendocrine system contributes to escalation of alcohol consumption and, similarly, chronic alcohol consumption contributes to disruption of the stress system. The CRF system also represents the central switchboard for regulating homeostasis, and more recent studies have found that stress and aberrations in the CRF pathway are implicated in accelerated aging and age-related neurodegenerative disease. Corticotropin releasing factor binding protein (CRFBP) is a secreted glycoprotein distributed in peripheral tissues and in specific brain regions. It neutralizes the effects of CRF by sequestering free CRF, but may also possess excitatory function by interacting with CRF receptors. CRFBP’s dual role in influencing CRF bioavailability and CRF receptor signaling has been shown to have a major part in the HPA axis response. Therefore, CRFBP may represent a valuable target to treat stress-related illness, including: development of novel medications to treat AUD and restore homeostasis in the aging brain. This narrative review focuses on molecular mechanisms related to the role of CRFBP in the progression of addictive and psychiatric disorders, biological aging, and age-related neurodegenerative disease. We provide an overview of recent studies investigating modulation of this pathway as a potential therapeutic target for AUD and age-related neurodegenerative disease.
format	article
author	Dallece E. Curley Dallece E. Curley Ashley E. Webb Ashley E. Webb Douglas J. Sheffler Douglas J. Sheffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler
author_facet	Dallece E. Curley Dallece E. Curley Ashley E. Webb Ashley E. Webb Douglas J. Sheffler Douglas J. Sheffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler Carolina L. Haass-Koffler
author_sort	Dallece E. Curley
title	Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
title_short	Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
title_full	Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
title_fullStr	Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
title_full_unstemmed	Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research
title_sort	corticotropin releasing factor binding protein as a novel target to restore brain homeostasis: lessons learned from alcohol use disorder research
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ffc762c6607344c09d06fbe13927e788
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Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research

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