Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells

Abstract Short modified oligonucleotides targeted at bacterial DNA or RNA could serve as antibacterial agents provided that they are efficiently taken up by bacterial cells. However, the uptake of such oligonucleotides is hindered by the bacterial cell wall. To overcome this problem, oligomers have...

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Autores principales: Marcin Równicki, Monika Wojciechowska, Aleksandra J. Wierzba, Jakub Czarnecki, Dariusz Bartosik, Dorota Gryko, Joanna Trylska
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ffca693ae9714fc6bf1940fa57b87fbc
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