Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review

Abstract Background Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that results in progressive and irreversible disability. Fatigue is one of the most common MS-related symptoms and is characterized by a persistent lack of energy that impairs daily function...

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Autores principales:	Abril Oliva Ramirez, Alexander Keenan, Olivia Kalau, Evelyn Worthington, Lucas Cohen, Sumeet Singh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Multiple sclerosis Fatigue Burden of illness Systematic review Prevalence Economic Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ffd2a7e67a9d482389fb429424bfe8c9
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spelling	oai:doaj.org-article:ffd2a7e67a9d482389fb429424bfe8c92021-12-05T12:08:50ZPrevalence and burden of multiple sclerosis-related fatigue: a systematic literature review10.1186/s12883-021-02396-11471-2377https://doaj.org/article/ffd2a7e67a9d482389fb429424bfe8c92021-12-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02396-1https://doaj.org/toc/1471-2377Abstract Background Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that results in progressive and irreversible disability. Fatigue is one of the most common MS-related symptoms and is characterized by a persistent lack of energy that impairs daily functioning. The burden of MS-related fatigue is complex and multidimensional, and to our knowledge, no systematic literature review has been conducted on this subject. The purpose of this study was to conduct a systematic literature review on the epidemiology and burden of fatigue in people with multiple sclerosis (pwMS). Methods Systematic searches were conducted in MEDLINE, Embase, and Evidence-Based Medicine Reviews to identify relevant studies of fatigue in pwMS. English-language records published from 2010 to January 2020 that met predefined eligibility criteria were included. We initially selected studies that reported quality of life (QoL) and economic outcomes according to categories of fatigue (e.g., fatigued vs non-fatigued). Studies assessing associations between economic outcomes and fatigue as a continuous measure were later included to supplement the available data. Results The search identified 8147 unique records, 54 of which met the inclusion criteria. Of these, 39 reported epidemiological outcomes, 11 reported QoL, and 9 reported economic outcomes. The supplementary screen for economic studies with fatigue as a continuous measure included an additional 20 records. Fatigue prevalence in pwMS ranged from 36.5 to 78.0%. MS-related fatigue was consistently associated with significantly lower QoL. Results on the economic impact of fatigue were heterogeneous, but most studies reported a significant association between presence or severity of fatigue and employment status, capacity to work, and sick leave. There was a gap in evidence regarding the direct costs of MS-related fatigue and the burden experienced by caregivers of pwMS. Conclusion Fatigue is a prevalent symptom in pwMS and is associated with considerable QoL and economic burden. There are gaps in the evidence related to the direct costs of MS-related fatigue and the burden of fatigue on caregivers. Addressing fatigue over the clinical course of the disease may improve health and economic outcomes for patients with MS.Abril Oliva RamirezAlexander KeenanOlivia KalauEvelyn WorthingtonLucas CohenSumeet SinghBMCarticleMultiple sclerosisFatigueBurden of illnessSystematic reviewPrevalenceEconomicNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple sclerosis Fatigue Burden of illness Systematic review Prevalence Economic Neurology. Diseases of the nervous system RC346-429
spellingShingle	Multiple sclerosis Fatigue Burden of illness Systematic review Prevalence Economic Neurology. Diseases of the nervous system RC346-429 Abril Oliva Ramirez Alexander Keenan Olivia Kalau Evelyn Worthington Lucas Cohen Sumeet Singh Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
description	Abstract Background Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that results in progressive and irreversible disability. Fatigue is one of the most common MS-related symptoms and is characterized by a persistent lack of energy that impairs daily functioning. The burden of MS-related fatigue is complex and multidimensional, and to our knowledge, no systematic literature review has been conducted on this subject. The purpose of this study was to conduct a systematic literature review on the epidemiology and burden of fatigue in people with multiple sclerosis (pwMS). Methods Systematic searches were conducted in MEDLINE, Embase, and Evidence-Based Medicine Reviews to identify relevant studies of fatigue in pwMS. English-language records published from 2010 to January 2020 that met predefined eligibility criteria were included. We initially selected studies that reported quality of life (QoL) and economic outcomes according to categories of fatigue (e.g., fatigued vs non-fatigued). Studies assessing associations between economic outcomes and fatigue as a continuous measure were later included to supplement the available data. Results The search identified 8147 unique records, 54 of which met the inclusion criteria. Of these, 39 reported epidemiological outcomes, 11 reported QoL, and 9 reported economic outcomes. The supplementary screen for economic studies with fatigue as a continuous measure included an additional 20 records. Fatigue prevalence in pwMS ranged from 36.5 to 78.0%. MS-related fatigue was consistently associated with significantly lower QoL. Results on the economic impact of fatigue were heterogeneous, but most studies reported a significant association between presence or severity of fatigue and employment status, capacity to work, and sick leave. There was a gap in evidence regarding the direct costs of MS-related fatigue and the burden experienced by caregivers of pwMS. Conclusion Fatigue is a prevalent symptom in pwMS and is associated with considerable QoL and economic burden. There are gaps in the evidence related to the direct costs of MS-related fatigue and the burden of fatigue on caregivers. Addressing fatigue over the clinical course of the disease may improve health and economic outcomes for patients with MS.
format	article
author	Abril Oliva Ramirez Alexander Keenan Olivia Kalau Evelyn Worthington Lucas Cohen Sumeet Singh
author_facet	Abril Oliva Ramirez Alexander Keenan Olivia Kalau Evelyn Worthington Lucas Cohen Sumeet Singh
author_sort	Abril Oliva Ramirez
title	Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
title_short	Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
title_full	Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
title_fullStr	Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
title_full_unstemmed	Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
title_sort	prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ffd2a7e67a9d482389fb429424bfe8c9
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Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review

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