Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.

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Autores principales:	Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu, Yechun Xu, Qiang Zhao, Beili Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffd3451ed1a64d6295cce87f44f382f2
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spelling	oai:doaj.org-article:ffd3451ed1a64d6295cce87f44f382f22021-12-02T15:40:02ZStructural basis for chemokine recognition and receptor activation of chemokine receptor CCR510.1038/s41467-021-24438-52041-1723https://doaj.org/article/ffd3451ed1a64d6295cce87f44f382f22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24438-5https://doaj.org/toc/2041-1723The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.Hui ZhangKun ChenQiuxiang TanQiang ShaoShuo HanChenhui ZhangCuiying YiXiaojing ChuYa ZhuYechun XuQiang ZhaoBeili WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Zhang Kun Chen Qiuxiang Tan Qiang Shao Shuo Han Chenhui Zhang Cuiying Yi Xiaojing Chu Ya Zhu Yechun Xu Qiang Zhao Beili Wu Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
description	The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.
format	article
author	Hui Zhang Kun Chen Qiuxiang Tan Qiang Shao Shuo Han Chenhui Zhang Cuiying Yi Xiaojing Chu Ya Zhu Yechun Xu Qiang Zhao Beili Wu
author_facet	Hui Zhang Kun Chen Qiuxiang Tan Qiang Shao Shuo Han Chenhui Zhang Cuiying Yi Xiaojing Chu Ya Zhu Yechun Xu Qiang Zhao Beili Wu
author_sort	Hui Zhang
title	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
title_short	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
title_full	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
title_fullStr	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
title_full_unstemmed	Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
title_sort	structural basis for chemokine recognition and receptor activation of chemokine receptor ccr5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffd3451ed1a64d6295cce87f44f382f2
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_version_	1718385910575267840

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

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