Assessing the cognitive status of Drosophila by the value-based feeding decision

Abstract Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay,...

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Autores principales:	Chih-Chieh Yu, Ferng-Chang Chang, Yong-Huei Hong, Jian-Chiuan Li, Po-Lin Chen, Chun-Hong Chen, Tzai-Wen Chiu, Tsai-Te Lu, Yun-Ming Wang, Chih-Fei Kao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ffd765fde7e544a691de86ad07299d6f
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spelling	oai:doaj.org-article:ffd765fde7e544a691de86ad07299d6f2021-12-02T18:02:21ZAssessing the cognitive status of Drosophila by the value-based feeding decision10.1038/s41514-021-00075-62056-3973https://doaj.org/article/ffd765fde7e544a691de86ad07299d6f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41514-021-00075-6https://doaj.org/toc/2056-3973Abstract Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.Chih-Chieh YuFerng-Chang ChangYong-Huei HongJian-Chiuan LiPo-Lin ChenChun-Hong ChenTzai-Wen ChiuTsai-Te LuYun-Ming WangChih-Fei KaoNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Chih-Chieh Yu Ferng-Chang Chang Yong-Huei Hong Jian-Chiuan Li Po-Lin Chen Chun-Hong Chen Tzai-Wen Chiu Tsai-Te Lu Yun-Ming Wang Chih-Fei Kao Assessing the cognitive status of Drosophila by the value-based feeding decision
description	Abstract Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.
format	article
author	Chih-Chieh Yu Ferng-Chang Chang Yong-Huei Hong Jian-Chiuan Li Po-Lin Chen Chun-Hong Chen Tzai-Wen Chiu Tsai-Te Lu Yun-Ming Wang Chih-Fei Kao
author_facet	Chih-Chieh Yu Ferng-Chang Chang Yong-Huei Hong Jian-Chiuan Li Po-Lin Chen Chun-Hong Chen Tzai-Wen Chiu Tsai-Te Lu Yun-Ming Wang Chih-Fei Kao
author_sort	Chih-Chieh Yu
title	Assessing the cognitive status of Drosophila by the value-based feeding decision
title_short	Assessing the cognitive status of Drosophila by the value-based feeding decision
title_full	Assessing the cognitive status of Drosophila by the value-based feeding decision
title_fullStr	Assessing the cognitive status of Drosophila by the value-based feeding decision
title_full_unstemmed	Assessing the cognitive status of Drosophila by the value-based feeding decision
title_sort	assessing the cognitive status of drosophila by the value-based feeding decision
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffd765fde7e544a691de86ad07299d6f
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Assessing the cognitive status of Drosophila by the value-based feeding decision

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