Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C. P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Silva Prado, Jose Carlos Alves-Filho, Claudio Medana, Geovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd75
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ffd766e4bb69453a8c45e742f2d6dd75
record_format	dspace
spelling	oai:doaj.org-article:ffd766e4bb69453a8c45e742f2d6dd752021-12-02T15:34:47ZInhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis10.1038/s41467-018-07698-62041-1723https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd752018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07698-6https://doaj.org/toc/2041-1723Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.Carlo C. CampaRangel L. SilvaJean P. MargariaTracey PiraliMatheus S. MattosLucas R. KraemerDiego C. ReisGiorgio GrosaFrancesca CopperiEduardo M. DalmarcoRoberto C. P. Lima-JúniorSilvio AprileValentina SalaFederica Dal BelloDouglas Silva PradoJose Carlos Alves-FilhoClaudio MedanaGeovanni D. CassaliGian Cesare TronMauro M. TeixeiraElisa CiraoloRemo C. RussoEmilio HirschNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlo C. Campa Rangel L. Silva Jean P. Margaria Tracey Pirali Matheus S. Mattos Lucas R. Kraemer Diego C. Reis Giorgio Grosa Francesca Copperi Eduardo M. Dalmarco Roberto C. P. Lima-Júnior Silvio Aprile Valentina Sala Federica Dal Bello Douglas Silva Prado Jose Carlos Alves-Filho Claudio Medana Geovanni D. Cassali Gian Cesare Tron Mauro M. Teixeira Elisa Ciraolo Remo C. Russo Emilio Hirsch Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
description	Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.
format	article
author	Carlo C. Campa Rangel L. Silva Jean P. Margaria Tracey Pirali Matheus S. Mattos Lucas R. Kraemer Diego C. Reis Giorgio Grosa Francesca Copperi Eduardo M. Dalmarco Roberto C. P. Lima-Júnior Silvio Aprile Valentina Sala Federica Dal Bello Douglas Silva Prado Jose Carlos Alves-Filho Claudio Medana Geovanni D. Cassali Gian Cesare Tron Mauro M. Teixeira Elisa Ciraolo Remo C. Russo Emilio Hirsch
author_facet	Carlo C. Campa Rangel L. Silva Jean P. Margaria Tracey Pirali Matheus S. Mattos Lucas R. Kraemer Diego C. Reis Giorgio Grosa Francesca Copperi Eduardo M. Dalmarco Roberto C. P. Lima-Júnior Silvio Aprile Valentina Sala Federica Dal Bello Douglas Silva Prado Jose Carlos Alves-Filho Claudio Medana Geovanni D. Cassali Gian Cesare Tron Mauro M. Teixeira Elisa Ciraolo Remo C. Russo Emilio Hirsch
author_sort	Carlo C. Campa
title	Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
title_short	Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
title_full	Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
title_fullStr	Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
title_full_unstemmed	Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
title_sort	inhalation of the prodrug pi3k inhibitor cl27c improves lung function in asthma and fibrosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd75
work_keys_str_mv	AT carloccampa inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT rangellsilva inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT jeanpmargaria inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT traceypirali inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT matheussmattos inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT lucasrkraemer inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT diegocreis inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT giorgiogrosa inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT francescacopperi inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT eduardomdalmarco inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT robertocplimajunior inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT silvioaprile inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT valentinasala inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT federicadalbello inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT douglassilvaprado inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT josecarlosalvesfilho inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT claudiomedana inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT geovannidcassali inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT giancesaretron inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT mauromteixeira inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT elisaciraolo inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT remocrusso inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis AT emiliohirsch inhalationoftheprodrugpi3kinhibitorcl27cimproveslungfunctioninasthmaandfibrosis
_version_	1718386758083674112

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

Ejemplares similares