Role of sperm DNA fragmentation in male factor infertility: A systematic review

Objective: To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation. Methods: A search of PubMed was conducted using the keywords ‘sperm DNA fragmentation’ and ‘male infertili...

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Autores principales:	Chak-Lam Cho, Ashok Agarwal
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/ffd88114961144e2935c49c7bf5c6984
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spelling	oai:doaj.org-article:ffd88114961144e2935c49c7bf5c69842021-12-02T10:12:19ZRole of sperm DNA fragmentation in male factor infertility: A systematic review2090-598X10.1016/j.aju.2017.11.002https://doaj.org/article/ffd88114961144e2935c49c7bf5c69842018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301365https://doaj.org/toc/2090-598XObjective: To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation. Methods: A search of PubMed was conducted using the keywords ‘sperm DNA fragmentation’ and ‘male infertility’. Studies in languages other than English were excluded. All identified studies were screened and clinical studies in humans were included. Results: In all, 150 articles were included for analysis. Current evidence supports the association between high SDF and poor reproductive outcomes for natural conception and intrauterine insemination. Although the relationship between high SDF and in vitro fertilisation and intracytoplasmic sperm injection is less clear, the negative implication of high SDF on pregnancy loss is evident. Various treatment strategies have been attempted with varying success. The predictive value of SDF testing on outcomes of natural pregnancy and assisted reproduction illustrates its value in clinical practice. Conclusion: The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed. Keywords: Sperm DNA fragmentation (SDF), Male infertility, Assisted reproductive technology (ART)Chak-Lam ChoAshok AgarwalTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 21-34 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Chak-Lam Cho Ashok Agarwal Role of sperm DNA fragmentation in male factor infertility: A systematic review
description	Objective: To summarise the latest evidence on the role of sperm DNA fragmentation (SDF) in male factor infertility, as SDF has been emerging as a valuable tool for male infertility evaluation. Methods: A search of PubMed was conducted using the keywords ‘sperm DNA fragmentation’ and ‘male infertility’. Studies in languages other than English were excluded. All identified studies were screened and clinical studies in humans were included. Results: In all, 150 articles were included for analysis. Current evidence supports the association between high SDF and poor reproductive outcomes for natural conception and intrauterine insemination. Although the relationship between high SDF and in vitro fertilisation and intracytoplasmic sperm injection is less clear, the negative implication of high SDF on pregnancy loss is evident. Various treatment strategies have been attempted with varying success. The predictive value of SDF testing on outcomes of natural pregnancy and assisted reproduction illustrates its value in clinical practice. Conclusion: The significant role of SDF in male factor infertility is supported by current evidence. The beneficial role of SDF testing in selection of varicocelectomy candidates, evaluation of patients with unexplained infertility and recurrent pregnancy loss, selection of the most appropriate assisted reproductive technique with highest success rate for infertile couples, and assessment of infertile men with modifiable lifestyle factors or gonadotoxin exposure has been recently proposed. Keywords: Sperm DNA fragmentation (SDF), Male infertility, Assisted reproductive technology (ART)
format	article
author	Chak-Lam Cho Ashok Agarwal
author_facet	Chak-Lam Cho Ashok Agarwal
author_sort	Chak-Lam Cho
title	Role of sperm DNA fragmentation in male factor infertility: A systematic review
title_short	Role of sperm DNA fragmentation in male factor infertility: A systematic review
title_full	Role of sperm DNA fragmentation in male factor infertility: A systematic review
title_fullStr	Role of sperm DNA fragmentation in male factor infertility: A systematic review
title_full_unstemmed	Role of sperm DNA fragmentation in male factor infertility: A systematic review
title_sort	role of sperm dna fragmentation in male factor infertility: a systematic review
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/ffd88114961144e2935c49c7bf5c6984
work_keys_str_mv	AT chaklamcho roleofspermdnafragmentationinmalefactorinfertilityasystematicreview AT ashokagarwal roleofspermdnafragmentationinmalefactorinfertilityasystematicreview
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Role of sperm DNA fragmentation in male factor infertility: A systematic review

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