Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush

Anti-N-methyl-D-aspartate receptor encephalitis (Anti-NMDARE) is a synaptic autoimmune encephalitis syndrome mainly affecting young females. An underlying tumor, most commonly ovarian teratomas in young females, may indicate a paraneoplastic syndrome. Prognostic factors of the clinical course of dis...

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Autores principales:	Schneider R., Brüne M., Breuer TG., Börnke C., Gold R., Juckel G.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2019
Materias:	anti-nmda receptor encephalitis delta brush psychosis epileptic seizures - catatonia immunotherapy intensive care Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ffd989b07ce74ccdaf890339fa87e1a1
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spelling	oai:doaj.org-article:ffd989b07ce74ccdaf890339fa87e1a12021-12-05T14:11:04ZEarly multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush2081-693610.1515/tnsci-2019-0039https://doaj.org/article/ffd989b07ce74ccdaf890339fa87e1a12019-10-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2019-0039https://doaj.org/toc/2081-6936Anti-N-methyl-D-aspartate receptor encephalitis (Anti-NMDARE) is a synaptic autoimmune encephalitis syndrome mainly affecting young females. An underlying tumor, most commonly ovarian teratomas in young females, may indicate a paraneoplastic syndrome. Prognostic factors of the clinical course of disease and outcome play a central role in view of early administration of second-line immunotherapy and intensive-care therapy. We report a case of severe Anti-NMDARE associated with unfavorable predictors including an extreme delta brush (EDB) electroencephalographic-pattern and high anti-NMDAR-antibody titers in the cerebral spinal fluid (CSF), which necessitated the admission to an intensive care unit. In spite of the poor prognosis, the patient completely recovered; we attribute this to an early escalation to second-line immunotherapy with rituximab and multidisciplinary intensive-care therapy. The present case underlines the relevance of multidisciplinary management for individuals with Anti-NMDARE.Schneider R.Brüne M.Breuer TG.Börnke C.Gold R.Juckel G.De Gruyterarticleanti-nmda receptor encephalitisdelta brushpsychosisepileptic seizures - catatoniaimmunotherapyintensive careNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 10, Iss 1, Pp 241-243 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-nmda receptor encephalitis delta brush psychosis epileptic seizures - catatonia immunotherapy intensive care Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	anti-nmda receptor encephalitis delta brush psychosis epileptic seizures - catatonia immunotherapy intensive care Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Schneider R. Brüne M. Breuer TG. Börnke C. Gold R. Juckel G. Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
description	Anti-N-methyl-D-aspartate receptor encephalitis (Anti-NMDARE) is a synaptic autoimmune encephalitis syndrome mainly affecting young females. An underlying tumor, most commonly ovarian teratomas in young females, may indicate a paraneoplastic syndrome. Prognostic factors of the clinical course of disease and outcome play a central role in view of early administration of second-line immunotherapy and intensive-care therapy. We report a case of severe Anti-NMDARE associated with unfavorable predictors including an extreme delta brush (EDB) electroencephalographic-pattern and high anti-NMDAR-antibody titers in the cerebral spinal fluid (CSF), which necessitated the admission to an intensive care unit. In spite of the poor prognosis, the patient completely recovered; we attribute this to an early escalation to second-line immunotherapy with rituximab and multidisciplinary intensive-care therapy. The present case underlines the relevance of multidisciplinary management for individuals with Anti-NMDARE.
format	article
author	Schneider R. Brüne M. Breuer TG. Börnke C. Gold R. Juckel G.
author_facet	Schneider R. Brüne M. Breuer TG. Börnke C. Gold R. Juckel G.
author_sort	Schneider R.
title	Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
title_short	Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
title_full	Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
title_fullStr	Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
title_full_unstemmed	Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush
title_sort	early multidisciplinary intensive-care therapy can improve outcome of severe anti-nmda-receptor encephalitis presenting with extreme delta brush
publisher	De Gruyter
publishDate	2019
url	https://doaj.org/article/ffd989b07ce74ccdaf890339fa87e1a1
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Early multidisciplinary intensive-care therapy can improve outcome of severe anti-NMDA-receptor encephalitis presenting with extreme delta brush

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