The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyse...

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Autores principales:	Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R. Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B. Alexandrov, Kevin M. Brown, David C. Wedge, Stephen Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffda5b58926c4a49be8ed66041ae4d4b
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spelling	oai:doaj.org-article:ffda5b58926c4a49be8ed66041ae4d4b2021-12-02T16:04:34ZThe genomic and epigenomic evolutionary history of papillary renal cell carcinomas10.1038/s41467-020-16546-52041-1723https://doaj.org/article/ffda5b58926c4a49be8ed66041ae4d4b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16546-5https://doaj.org/toc/2041-1723Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyses.Bin ZhuMaria Luana PoetaManuela CostantiniTongwu ZhangJianxin ShiSteno SentinelliWei ZhaoVincenzo PompeoMaurizio CardelliBoian S. AlexandrovBurcak OtluXing HuaKristine JonesSeth BrodieMalgorzata Ewa DabrowskaJorge R. ToroMeredith YeagerMingyi WangBelynda HicksLudmil B. AlexandrovKevin M. BrownDavid C. WedgeStephen ChanockVito Michele FazioMichele GallucciMaria Teresa LandiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Zhu Maria Luana Poeta Manuela Costantini Tongwu Zhang Jianxin Shi Steno Sentinelli Wei Zhao Vincenzo Pompeo Maurizio Cardelli Boian S. Alexandrov Burcak Otlu Xing Hua Kristine Jones Seth Brodie Malgorzata Ewa Dabrowska Jorge R. Toro Meredith Yeager Mingyi Wang Belynda Hicks Ludmil B. Alexandrov Kevin M. Brown David C. Wedge Stephen Chanock Vito Michele Fazio Michele Gallucci Maria Teresa Landi The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
description	Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyses.
format	article
author	Bin Zhu Maria Luana Poeta Manuela Costantini Tongwu Zhang Jianxin Shi Steno Sentinelli Wei Zhao Vincenzo Pompeo Maurizio Cardelli Boian S. Alexandrov Burcak Otlu Xing Hua Kristine Jones Seth Brodie Malgorzata Ewa Dabrowska Jorge R. Toro Meredith Yeager Mingyi Wang Belynda Hicks Ludmil B. Alexandrov Kevin M. Brown David C. Wedge Stephen Chanock Vito Michele Fazio Michele Gallucci Maria Teresa Landi
author_facet	Bin Zhu Maria Luana Poeta Manuela Costantini Tongwu Zhang Jianxin Shi Steno Sentinelli Wei Zhao Vincenzo Pompeo Maurizio Cardelli Boian S. Alexandrov Burcak Otlu Xing Hua Kristine Jones Seth Brodie Malgorzata Ewa Dabrowska Jorge R. Toro Meredith Yeager Mingyi Wang Belynda Hicks Ludmil B. Alexandrov Kevin M. Brown David C. Wedge Stephen Chanock Vito Michele Fazio Michele Gallucci Maria Teresa Landi
author_sort	Bin Zhu
title	The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
title_short	The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
title_full	The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
title_fullStr	The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
title_full_unstemmed	The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
title_sort	genomic and epigenomic evolutionary history of papillary renal cell carcinomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ffda5b58926c4a49be8ed66041ae4d4b
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The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

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