Respiratory pathogens adopt a chronic lifestyle in response to bile.

Chronic respiratory infections are a major cause of morbidity and mortality, most particularly in Cystic Fibrosis (CF) patients. The recent finding that gastro-esophageal reflux (GER) frequently occurs in CF patients led us to investigate the impact of bile on the behaviour of Pseudomonas aeruginosa...

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Autores principales:	F Jerry Reen, David F Woods, Marlies J Mooij, Claire Adams, Fergal O'Gara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffdb8af3ef0c47f58514aba4cf22a13a
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spelling	oai:doaj.org-article:ffdb8af3ef0c47f58514aba4cf22a13a2021-11-18T08:13:52ZRespiratory pathogens adopt a chronic lifestyle in response to bile.1932-620310.1371/journal.pone.0045978https://doaj.org/article/ffdb8af3ef0c47f58514aba4cf22a13a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049911/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Chronic respiratory infections are a major cause of morbidity and mortality, most particularly in Cystic Fibrosis (CF) patients. The recent finding that gastro-esophageal reflux (GER) frequently occurs in CF patients led us to investigate the impact of bile on the behaviour of Pseudomonas aeruginosa and other CF-associated respiratory pathogens. Bile increased biofilm formation, Type Six Secretion, and quorum sensing in P. aeruginosa, all of which are associated with the switch from acute to persistent infection. Furthermore, bile negatively influenced Type Three Secretion and swarming motility in P. aeruginosa, phenotypes associated with acute infection. Bile also modulated biofilm formation in a range of other CF-associated respiratory pathogens, including Burkholderia cepacia and Staphylococcus aureus. Therefore, our results suggest that GER-derived bile may be a host determinant contributing to chronic respiratory infection.F Jerry ReenDavid F WoodsMarlies J MooijClaire AdamsFergal O'GaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45978 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F Jerry Reen David F Woods Marlies J Mooij Claire Adams Fergal O'Gara Respiratory pathogens adopt a chronic lifestyle in response to bile.
description	Chronic respiratory infections are a major cause of morbidity and mortality, most particularly in Cystic Fibrosis (CF) patients. The recent finding that gastro-esophageal reflux (GER) frequently occurs in CF patients led us to investigate the impact of bile on the behaviour of Pseudomonas aeruginosa and other CF-associated respiratory pathogens. Bile increased biofilm formation, Type Six Secretion, and quorum sensing in P. aeruginosa, all of which are associated with the switch from acute to persistent infection. Furthermore, bile negatively influenced Type Three Secretion and swarming motility in P. aeruginosa, phenotypes associated with acute infection. Bile also modulated biofilm formation in a range of other CF-associated respiratory pathogens, including Burkholderia cepacia and Staphylococcus aureus. Therefore, our results suggest that GER-derived bile may be a host determinant contributing to chronic respiratory infection.
format	article
author	F Jerry Reen David F Woods Marlies J Mooij Claire Adams Fergal O'Gara
author_facet	F Jerry Reen David F Woods Marlies J Mooij Claire Adams Fergal O'Gara
author_sort	F Jerry Reen
title	Respiratory pathogens adopt a chronic lifestyle in response to bile.
title_short	Respiratory pathogens adopt a chronic lifestyle in response to bile.
title_full	Respiratory pathogens adopt a chronic lifestyle in response to bile.
title_fullStr	Respiratory pathogens adopt a chronic lifestyle in response to bile.
title_full_unstemmed	Respiratory pathogens adopt a chronic lifestyle in response to bile.
title_sort	respiratory pathogens adopt a chronic lifestyle in response to bile.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ffdb8af3ef0c47f58514aba4cf22a13a
work_keys_str_mv	AT fjerryreen respiratorypathogensadoptachroniclifestyleinresponsetobile AT davidfwoods respiratorypathogensadoptachroniclifestyleinresponsetobile AT marliesjmooij respiratorypathogensadoptachroniclifestyleinresponsetobile AT claireadams respiratorypathogensadoptachroniclifestyleinresponsetobile AT fergalogara respiratorypathogensadoptachroniclifestyleinresponsetobile
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Respiratory pathogens adopt a chronic lifestyle in response to bile.

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