Adipose HuR protects against diet-induced obesity and insulin resistance

Adipose HuR protects against diet-induced obesity and insulin resistance

Human antigen R (HuR) is a RNA-binding protein. Here the authors investigate its role in adipose tissue and find that it protects mice from diet-induced obesity, prevents adipocyte hypertrophy, and promotes lipolysis, which may at least in part be due to HuR-dependent ATGL mRNA stability regulation...

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Autores principales: Jingyuan Li, Li Gong, Shaozhuang Liu, Yujie Zhang, Chunmei Zhang, Mi Tian, Huixia Lu, Peili Bu, Jianmin Yang, Changhan Ouyang, Xiuxin Jiang, Jiliang Wu, Yun Zhang, Qing Min, Cheng Zhang, Wencheng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ffdb9416baef42e0a24754e394971a46
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spelling oai:doaj.org-article:ffdb9416baef42e0a24754e394971a462021-12-02T16:57:07ZAdipose HuR protects against diet-induced obesity and insulin resistance10.1038/s41467-019-10348-02041-1723https://doaj.org/article/ffdb9416baef42e0a24754e394971a462019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10348-0https://doaj.org/toc/2041-1723Human antigen R (HuR) is a RNA-binding protein. Here the authors investigate its role in adipose tissue and find that it protects mice from diet-induced obesity, prevents adipocyte hypertrophy, and promotes lipolysis, which may at least in part be due to HuR-dependent ATGL mRNA stability regulation demonstrated in-vitro.Jingyuan LiLi GongShaozhuang LiuYujie ZhangChunmei ZhangMi TianHuixia LuPeili BuJianmin YangChanghan OuyangXiuxin JiangJiliang WuYun ZhangQing MinCheng ZhangWencheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jingyuan Li
Li Gong
Shaozhuang Liu
Yujie Zhang
Chunmei Zhang
Mi Tian
Huixia Lu
Peili Bu
Jianmin Yang
Changhan Ouyang
Xiuxin Jiang
Jiliang Wu
Yun Zhang
Qing Min
Cheng Zhang
Wencheng Zhang
Adipose HuR protects against diet-induced obesity and insulin resistance
description Human antigen R (HuR) is a RNA-binding protein. Here the authors investigate its role in adipose tissue and find that it protects mice from diet-induced obesity, prevents adipocyte hypertrophy, and promotes lipolysis, which may at least in part be due to HuR-dependent ATGL mRNA stability regulation demonstrated in-vitro.
format article
author Jingyuan Li
Li Gong
Shaozhuang Liu
Yujie Zhang
Chunmei Zhang
Mi Tian
Huixia Lu
Peili Bu
Jianmin Yang
Changhan Ouyang
Xiuxin Jiang
Jiliang Wu
Yun Zhang
Qing Min
Cheng Zhang
Wencheng Zhang
author_facet Jingyuan Li
Li Gong
Shaozhuang Liu
Yujie Zhang
Chunmei Zhang
Mi Tian
Huixia Lu
Peili Bu
Jianmin Yang
Changhan Ouyang
Xiuxin Jiang
Jiliang Wu
Yun Zhang
Qing Min
Cheng Zhang
Wencheng Zhang
author_sort Jingyuan Li
title Adipose HuR protects against diet-induced obesity and insulin resistance
title_short Adipose HuR protects against diet-induced obesity and insulin resistance
title_full Adipose HuR protects against diet-induced obesity and insulin resistance
title_fullStr Adipose HuR protects against diet-induced obesity and insulin resistance
title_full_unstemmed Adipose HuR protects against diet-induced obesity and insulin resistance
title_sort adipose hur protects against diet-induced obesity and insulin resistance
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ffdb9416baef42e0a24754e394971a46
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AT ligong adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT shaozhuangliu adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT yujiezhang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT chunmeizhang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT mitian adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT huixialu adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT peilibu adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT jianminyang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT changhanouyang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT xiuxinjiang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT jiliangwu adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT yunzhang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT qingmin adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT chengzhang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
AT wenchengzhang adiposehurprotectsagainstdietinducedobesityandinsulinresistance
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