Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter...
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Nature Portfolio
2018
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oai:doaj.org-article:ffdbab560c8441628effd5dbb028717d2021-12-02T16:56:55ZNovel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways10.1038/s41467-018-06649-52041-1723https://doaj.org/article/ffdbab560c8441628effd5dbb028717d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06649-5https://doaj.org/toc/2041-1723Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count.David L. DuffyGu ZhuXin LiMarianna SannaMark M. IlesLeonie C. JacobsDavid M. EvansSeyhan YazarJonathan BeesleyMatthew H. LawPeter KraftAlessia ViscontiJohn C. TaylorFan LiuMargaret J. WrightAnjali K. HendersLisa BowdlerDan GlassM. Arfan IkramAndré G. UitterlindenPamela A. MaddenAndrew C. HeathElliot C. NelsonAdele C. GreenStephen ChanockJennifer H. BarrettMatthew A. BrownNicholas K. HaywardStuart MacGregorRichard A. SturmAlex W. HewittMelanoma GWAS ConsortiumManfred KayserDavid J. HunterJulia A. Newton BishopTimothy D. SpectorGrant W. MontgomeryDavid A. MackeyGeorge Davey SmithTamar E. NijstenD. Timothy BishopVeronique BatailleMario FalchiJiali HanNicholas G. MartinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David L. Duffy Gu Zhu Xin Li Marianna Sanna Mark M. Iles Leonie C. Jacobs David M. Evans Seyhan Yazar Jonathan Beesley Matthew H. Law Peter Kraft Alessia Visconti John C. Taylor Fan Liu Margaret J. Wright Anjali K. Henders Lisa Bowdler Dan Glass M. Arfan Ikram André G. Uitterlinden Pamela A. Madden Andrew C. Heath Elliot C. Nelson Adele C. Green Stephen Chanock Jennifer H. Barrett Matthew A. Brown Nicholas K. Hayward Stuart MacGregor Richard A. Sturm Alex W. Hewitt Melanoma GWAS Consortium Manfred Kayser David J. Hunter Julia A. Newton Bishop Timothy D. Spector Grant W. Montgomery David A. Mackey George Davey Smith Tamar E. Nijsten D. Timothy Bishop Veronique Bataille Mario Falchi Jiali Han Nicholas G. Martin Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| description |
Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count. |
| format |
article |
| author |
David L. Duffy Gu Zhu Xin Li Marianna Sanna Mark M. Iles Leonie C. Jacobs David M. Evans Seyhan Yazar Jonathan Beesley Matthew H. Law Peter Kraft Alessia Visconti John C. Taylor Fan Liu Margaret J. Wright Anjali K. Henders Lisa Bowdler Dan Glass M. Arfan Ikram André G. Uitterlinden Pamela A. Madden Andrew C. Heath Elliot C. Nelson Adele C. Green Stephen Chanock Jennifer H. Barrett Matthew A. Brown Nicholas K. Hayward Stuart MacGregor Richard A. Sturm Alex W. Hewitt Melanoma GWAS Consortium Manfred Kayser David J. Hunter Julia A. Newton Bishop Timothy D. Spector Grant W. Montgomery David A. Mackey George Davey Smith Tamar E. Nijsten D. Timothy Bishop Veronique Bataille Mario Falchi Jiali Han Nicholas G. Martin |
| author_facet |
David L. Duffy Gu Zhu Xin Li Marianna Sanna Mark M. Iles Leonie C. Jacobs David M. Evans Seyhan Yazar Jonathan Beesley Matthew H. Law Peter Kraft Alessia Visconti John C. Taylor Fan Liu Margaret J. Wright Anjali K. Henders Lisa Bowdler Dan Glass M. Arfan Ikram André G. Uitterlinden Pamela A. Madden Andrew C. Heath Elliot C. Nelson Adele C. Green Stephen Chanock Jennifer H. Barrett Matthew A. Brown Nicholas K. Hayward Stuart MacGregor Richard A. Sturm Alex W. Hewitt Melanoma GWAS Consortium Manfred Kayser David J. Hunter Julia A. Newton Bishop Timothy D. Spector Grant W. Montgomery David A. Mackey George Davey Smith Tamar E. Nijsten D. Timothy Bishop Veronique Bataille Mario Falchi Jiali Han Nicholas G. Martin |
| author_sort |
David L. Duffy |
| title |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| title_short |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| title_full |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| title_fullStr |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| title_full_unstemmed |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| title_sort |
novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ffdbab560c8441628effd5dbb028717d |
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