Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population

Abstract This paper evaluates the forensic utility of 30 insertion-deletion polymorphism (indel) markers in a sample from the Bahraini population using the Qiagen Investigator DIPplex Kit. Allele frequencies and forensic stats of the 30 indels were investigated in 293 unrelated individuals from diff...

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Autores principales:	Noora R. Al-Snan, Sabah Shabbir, Sahar S. Baksh, Mashael AlQerainees, Mahdi Haidar, Safia A. Messaoudi, Moiz Bakhiet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffe514a8100c45ab85efd30fb600c148
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spelling	oai:doaj.org-article:ffe514a8100c45ab85efd30fb600c1482021-12-02T13:24:13ZPopulation genetics of 30 insertion/deletion polymorphisms in the Bahraini population10.1038/s41598-021-86386-w2045-2322https://doaj.org/article/ffe514a8100c45ab85efd30fb600c1482021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86386-whttps://doaj.org/toc/2045-2322Abstract This paper evaluates the forensic utility of 30 insertion-deletion polymorphism (indel) markers in a sample from the Bahraini population using the Qiagen Investigator DIPplex Kit. Allele frequencies and forensic stats of the 30 indels were investigated in 293 unrelated individuals from different governorates of the Kingdom of Bahrain. None of the markers showed significant deviation from Hardy Weinberg equilibrium except for HLD88 locus and no linkage disequilibrium were detected between all possible pair of the indel loci, assuming that these markers are independent and their allele frequencies can be used to calculate the match probabilities in the Bahraini population. The high power of discrimination (CPD = 0.9999999999998110) and the low combined match probability (CPM = 1.89 × 10−13) indicate that these markers are informative and can be successfully used for human identification in terms of forensics and paternity. Genetic distances and relatedness were displayed through multidimensional plotting and phylogenetic tree using various populations in the region. Our study showed that the Bahraini population was clustered with neighboring countries such as Kuwait and Emirates which indicates that these closely geographical regions share similar allele frequencies and are more genetically related than other reference population studied.Noora R. Al-SnanSabah ShabbirSahar S. BakshMashael AlQeraineesMahdi HaidarSafia A. MessaoudiMoiz BakhietNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noora R. Al-Snan Sabah Shabbir Sahar S. Baksh Mashael AlQerainees Mahdi Haidar Safia A. Messaoudi Moiz Bakhiet Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
description	Abstract This paper evaluates the forensic utility of 30 insertion-deletion polymorphism (indel) markers in a sample from the Bahraini population using the Qiagen Investigator DIPplex Kit. Allele frequencies and forensic stats of the 30 indels were investigated in 293 unrelated individuals from different governorates of the Kingdom of Bahrain. None of the markers showed significant deviation from Hardy Weinberg equilibrium except for HLD88 locus and no linkage disequilibrium were detected between all possible pair of the indel loci, assuming that these markers are independent and their allele frequencies can be used to calculate the match probabilities in the Bahraini population. The high power of discrimination (CPD = 0.9999999999998110) and the low combined match probability (CPM = 1.89 × 10−13) indicate that these markers are informative and can be successfully used for human identification in terms of forensics and paternity. Genetic distances and relatedness were displayed through multidimensional plotting and phylogenetic tree using various populations in the region. Our study showed that the Bahraini population was clustered with neighboring countries such as Kuwait and Emirates which indicates that these closely geographical regions share similar allele frequencies and are more genetically related than other reference population studied.
format	article
author	Noora R. Al-Snan Sabah Shabbir Sahar S. Baksh Mashael AlQerainees Mahdi Haidar Safia A. Messaoudi Moiz Bakhiet
author_facet	Noora R. Al-Snan Sabah Shabbir Sahar S. Baksh Mashael AlQerainees Mahdi Haidar Safia A. Messaoudi Moiz Bakhiet
author_sort	Noora R. Al-Snan
title	Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
title_short	Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
title_full	Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
title_fullStr	Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
title_full_unstemmed	Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population
title_sort	population genetics of 30 insertion/deletion polymorphisms in the bahraini population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffe514a8100c45ab85efd30fb600c148
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Population genetics of 30 insertion/deletion polymorphisms in the Bahraini population

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