GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.

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Autores principales: Martin Heubl, Jinwei Zhang, Jessica C. Pressey, Sana Al Awabdh, Marianne Renner, Ferran Gomez-Castro, Imane Moutkine, Emmanuel Eugène, Marion Russeau, Kristopher T. Kahle, Jean Christophe Poncer, Sabine Lévi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ffe6f5b911a744c6953dd07c6b189a0b
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spelling oai:doaj.org-article:ffe6f5b911a744c6953dd07c6b189a0b2021-12-02T15:38:59ZGABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase10.1038/s41467-017-01749-02041-1723https://doaj.org/article/ffe6f5b911a744c6953dd07c6b189a0b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01749-0https://doaj.org/toc/2041-1723GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.Martin HeublJinwei ZhangJessica C. PresseySana Al AwabdhMarianne RennerFerran Gomez-CastroImane MoutkineEmmanuel EugèneMarion RusseauKristopher T. KahleJean Christophe PoncerSabine LéviNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin Heubl
Jinwei Zhang
Jessica C. Pressey
Sana Al Awabdh
Marianne Renner
Ferran Gomez-Castro
Imane Moutkine
Emmanuel Eugène
Marion Russeau
Kristopher T. Kahle
Jean Christophe Poncer
Sabine Lévi
GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
description GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.
format article
author Martin Heubl
Jinwei Zhang
Jessica C. Pressey
Sana Al Awabdh
Marianne Renner
Ferran Gomez-Castro
Imane Moutkine
Emmanuel Eugène
Marion Russeau
Kristopher T. Kahle
Jean Christophe Poncer
Sabine Lévi
author_facet Martin Heubl
Jinwei Zhang
Jessica C. Pressey
Sana Al Awabdh
Marianne Renner
Ferran Gomez-Castro
Imane Moutkine
Emmanuel Eugène
Marion Russeau
Kristopher T. Kahle
Jean Christophe Poncer
Sabine Lévi
author_sort Martin Heubl
title GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
title_short GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
title_full GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
title_fullStr GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
title_full_unstemmed GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase
title_sort gabaa receptor dependent synaptic inhibition rapidly tunes kcc2 activity via the cl−-sensitive wnk1 kinase
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ffe6f5b911a744c6953dd07c6b189a0b
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