Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis

Abstract To evaluate overall survival and locoregional recurrence between patients with invasive breast tumours and sentinel node metastasis undergoing sentinel lymph node dissection (SLND) alone and those undergoing complete axillary lymph node dissection (ALND). In this retrospective cohort study,...

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Autores principales:	Vanessa Monteiro Sanvido, Simone Elias, Gil Facina, Silvio Eduardo Bromberg, Afonso Celso Pinto Nazário
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ffe7626b5c2b40debaef49a373359406
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spelling	oai:doaj.org-article:ffe7626b5c2b40debaef49a3733594062021-12-02T17:13:17ZSurvival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis10.1038/s41598-021-99359-w2045-2322https://doaj.org/article/ffe7626b5c2b40debaef49a3733594062021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99359-whttps://doaj.org/toc/2045-2322Abstract To evaluate overall survival and locoregional recurrence between patients with invasive breast tumours and sentinel node metastasis undergoing sentinel lymph node dissection (SLND) alone and those undergoing complete axillary lymph node dissection (ALND). In this retrospective cohort study, we reviewed the medical records of patients with invasive breast carcinoma who underwent lumpectomy at a public university hospital in Brazil between 2008 and 2018. We evaluated the overall survival and the locoregional recurrence using Kaplan–Meier and Cox regression analyses, respectively. Overall, 97 participants who underwent lumpectomy were enroled; 41 in the ALND group, and 56 in the SLND group, according to Z0011 criteria. Only 17% of the patients in the ALND group had an additional biopsy-proven axillary disease, and 83% were treated with complete dissection unnecessarily. The 5-year survival rates were 80.1% and 87.5% for SLND and ALND, respectively (p = 0.376). Locoregional recurrence was rare (1.7% and 7.3% in the SLND and ALND, respectively; p = 0.3075). Overall survival and locoregional recurrence were similar between the two groups. The de-escalation of ALND to SLND in women with metastasis in the sentinel lymph node treated with conservative surgery and radiotherapy that meet the Z0011 criteria is feasible even in developing countries.Vanessa Monteiro SanvidoSimone EliasGil FacinaSilvio Eduardo BrombergAfonso Celso Pinto NazárioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa Monteiro Sanvido Simone Elias Gil Facina Silvio Eduardo Bromberg Afonso Celso Pinto Nazário Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
description	Abstract To evaluate overall survival and locoregional recurrence between patients with invasive breast tumours and sentinel node metastasis undergoing sentinel lymph node dissection (SLND) alone and those undergoing complete axillary lymph node dissection (ALND). In this retrospective cohort study, we reviewed the medical records of patients with invasive breast carcinoma who underwent lumpectomy at a public university hospital in Brazil between 2008 and 2018. We evaluated the overall survival and the locoregional recurrence using Kaplan–Meier and Cox regression analyses, respectively. Overall, 97 participants who underwent lumpectomy were enroled; 41 in the ALND group, and 56 in the SLND group, according to Z0011 criteria. Only 17% of the patients in the ALND group had an additional biopsy-proven axillary disease, and 83% were treated with complete dissection unnecessarily. The 5-year survival rates were 80.1% and 87.5% for SLND and ALND, respectively (p = 0.376). Locoregional recurrence was rare (1.7% and 7.3% in the SLND and ALND, respectively; p = 0.3075). Overall survival and locoregional recurrence were similar between the two groups. The de-escalation of ALND to SLND in women with metastasis in the sentinel lymph node treated with conservative surgery and radiotherapy that meet the Z0011 criteria is feasible even in developing countries.
format	article
author	Vanessa Monteiro Sanvido Simone Elias Gil Facina Silvio Eduardo Bromberg Afonso Celso Pinto Nazário
author_facet	Vanessa Monteiro Sanvido Simone Elias Gil Facina Silvio Eduardo Bromberg Afonso Celso Pinto Nazário
author_sort	Vanessa Monteiro Sanvido
title	Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
title_short	Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
title_full	Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
title_fullStr	Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
title_full_unstemmed	Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
title_sort	survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ffe7626b5c2b40debaef49a373359406
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Survival and recurrence with or without axillary dissection in patients with invasive breast cancer and sentinel node metastasis

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