Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.

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Autores principales:	Tao Yu, Shucheng Gan, Qingchen Zhu, Dongfang Dai, Ni Li, Hui Wang, Xiaosong Chen, Dan Hou, Yan Wang, Qiang Pan, Jing Xu, Xingli Zhang, Junli Liu, Siyu Pei, Chao Peng, Ping Wu, Simona Romano, Chaoming Mao, Mingzhu Huang, Xiaodong Zhu, Kunwei Shen, Jun Qin, Yichuan Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffe86352abb942749508c0cd964943a7
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spelling	oai:doaj.org-article:ffe86352abb942749508c0cd964943a72021-12-02T16:57:33ZModulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim2410.1038/s41467-019-12384-22041-1723https://doaj.org/article/ffe86352abb942749508c0cd964943a72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12384-2https://doaj.org/toc/2041-1723Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.Tao YuShucheng GanQingchen ZhuDongfang DaiNi LiHui WangXiaosong ChenDan HouYan WangQiang PanJing XuXingli ZhangJunli LiuSiyu PeiChao PengPing WuSimona RomanoChaoming MaoMingzhu HuangXiaodong ZhuKunwei ShenJun QinYichuan XiaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Yu Shucheng Gan Qingchen Zhu Dongfang Dai Ni Li Hui Wang Xiaosong Chen Dan Hou Yan Wang Qiang Pan Jing Xu Xingli Zhang Junli Liu Siyu Pei Chao Peng Ping Wu Simona Romano Chaoming Mao Mingzhu Huang Xiaodong Zhu Kunwei Shen Jun Qin Yichuan Xiao Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
description	Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.
format	article
author	Tao Yu Shucheng Gan Qingchen Zhu Dongfang Dai Ni Li Hui Wang Xiaosong Chen Dan Hou Yan Wang Qiang Pan Jing Xu Xingli Zhang Junli Liu Siyu Pei Chao Peng Ping Wu Simona Romano Chaoming Mao Mingzhu Huang Xiaodong Zhu Kunwei Shen Jun Qin Yichuan Xiao
author_facet	Tao Yu Shucheng Gan Qingchen Zhu Dongfang Dai Ni Li Hui Wang Xiaosong Chen Dan Hou Yan Wang Qiang Pan Jing Xu Xingli Zhang Junli Liu Siyu Pei Chao Peng Ping Wu Simona Romano Chaoming Mao Mingzhu Huang Xiaodong Zhu Kunwei Shen Jun Qin Yichuan Xiao
author_sort	Tao Yu
title	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
title_short	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
title_full	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
title_fullStr	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
title_full_unstemmed	Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24
title_sort	modulation of m2 macrophage polarization by the crosstalk between stat6 and trim24
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ffe86352abb942749508c0cd964943a7
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Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

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