Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

Stat6 promotes M2 macrophage polarization. Here the authors characterize Trim24-CBP-Stat6 circuit regulating M2 macrophage polarization via Stat6 acetylation, and show it contributes to pro-tumorigenic macrophage activity in mice.

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Autores principales: Tao Yu, Shucheng Gan, Qingchen Zhu, Dongfang Dai, Ni Li, Hui Wang, Xiaosong Chen, Dan Hou, Yan Wang, Qiang Pan, Jing Xu, Xingli Zhang, Junli Liu, Siyu Pei, Chao Peng, Ping Wu, Simona Romano, Chaoming Mao, Mingzhu Huang, Xiaodong Zhu, Kunwei Shen, Jun Qin, Yichuan Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/ffe86352abb942749508c0cd964943a7
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