PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy
Yuhui Qiao, Baoling Zhu, Aiju Tian, Zijian Li Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ffebd9edd7654815a5149bd3b3c94e28 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ffebd9edd7654815a5149bd3b3c94e28 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ffebd9edd7654815a5149bd3b3c94e282021-12-02T03:11:36ZPEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy1178-2013https://doaj.org/article/ffebd9edd7654815a5149bd3b3c94e282017-07-01T00:00:00Zhttps://www.dovepress.com/peg-coated-gold-nanoparticles-attenuate-beta-adrenergic-receptor-media-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuhui Qiao, Baoling Zhu, Aiju Tian, Zijian Li Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, People’s Republic of China Abstract: Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis. AuNPs exerted an anti-cardiac hypertrophy effect by decreasing β1-AR expression and its downstream ERK1/2 hypertrophic pathway. Our results indicated that AuNPs might be safe and have the potential to be used as multi-functional materials (drug carrier systems and anti-cardiac hypertrophy agents). Keywords: AuNPs, cardiac hypertrophy, β-adrenergic receptor, ERK1/2 signaling pathwayQiao YHZhu BLTian AJLi ZJDove Medical PressarticleAuNPsCardiac hypertrophyβ-adrenergic receptorERK1/2 signalling pathwayMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4709-4719 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
AuNPs Cardiac hypertrophy β-adrenergic receptor ERK1/2 signalling pathway Medicine (General) R5-920 |
| spellingShingle |
AuNPs Cardiac hypertrophy β-adrenergic receptor ERK1/2 signalling pathway Medicine (General) R5-920 Qiao YH Zhu BL Tian AJ Li ZJ PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| description |
Yuhui Qiao, Baoling Zhu, Aiju Tian, Zijian Li Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, People’s Republic of China Abstract: Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis. AuNPs exerted an anti-cardiac hypertrophy effect by decreasing β1-AR expression and its downstream ERK1/2 hypertrophic pathway. Our results indicated that AuNPs might be safe and have the potential to be used as multi-functional materials (drug carrier systems and anti-cardiac hypertrophy agents). Keywords: AuNPs, cardiac hypertrophy, β-adrenergic receptor, ERK1/2 signaling pathway |
| format |
article |
| author |
Qiao YH Zhu BL Tian AJ Li ZJ |
| author_facet |
Qiao YH Zhu BL Tian AJ Li ZJ |
| author_sort |
Qiao YH |
| title |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| title_short |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| title_full |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| title_fullStr |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| title_full_unstemmed |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| title_sort |
peg-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/ffebd9edd7654815a5149bd3b3c94e28 |
| work_keys_str_mv |
AT qiaoyh pegcoatedgoldnanoparticlesattenuatebetaadrenergicreceptormediatedcardiachypertrophy AT zhubl pegcoatedgoldnanoparticlesattenuatebetaadrenergicreceptormediatedcardiachypertrophy AT tianaj pegcoatedgoldnanoparticlesattenuatebetaadrenergicreceptormediatedcardiachypertrophy AT lizj pegcoatedgoldnanoparticlesattenuatebetaadrenergicreceptormediatedcardiachypertrophy |
| _version_ |
1718401959162019840 |