Renewed proliferation in adult mouse cochlea and regeneration of hair cells

The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.

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Detalles Bibliográficos
Autores principales: Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li, Zheng-Yi Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c57
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Sumario:The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.