Renewed proliferation in adult mouse cochlea and regeneration of hair cells

The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.

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Detalles Bibliográficos
Autores principales:	Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li, Zheng-Yi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c57
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spelling	oai:doaj.org-article:ffede07f9adb4b84bc66e2e78aa02c572021-12-02T17:02:17ZRenewed proliferation in adult mouse cochlea and regeneration of hair cells10.1038/s41467-019-13157-72041-1723https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c572019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13157-7https://doaj.org/toc/2041-1723The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.Yilai ShuWenyan LiMingqian HuangYi-Zhou QuanDeborah SchefferChunjie TianYong TaoXuezhong LiuKonrad HochedlingerArtur A. IndzhykulianZhengmin WangHuawei LiZheng-Yi ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen Renewed proliferation in adult mouse cochlea and regeneration of hair cells
description	The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.
format	article
author	Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen
author_facet	Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen
author_sort	Yilai Shu
title	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_short	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_full	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_fullStr	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_full_unstemmed	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_sort	renewed proliferation in adult mouse cochlea and regeneration of hair cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ffede07f9adb4b84bc66e2e78aa02c57
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Renewed proliferation in adult mouse cochlea and regeneration of hair cells

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