Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.

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Autores principales:	Ellen Brenner, Barbara F. Schörg, Fatima Ahmetlić, Thomas Wieder, Franz Joachim Hilke, Nadine Simon, Christopher Schroeder, German Demidov, Tanja Riedel, Birgit Fehrenbacher, Martin Schaller, Andrea Forschner, Thomas Eigentler, Heike Niessner, Tobias Sinnberg, Katharina S. Böhm, Nadine Hömberg, Heidi Braumüller, Daniel Dauch, Stefan Zwirner, Lars Zender, Dominik Sonanini, Albert Geishauser, Jürgen Bauer, Martin Eichner, Katja J. Jarick, Andreas Beilhack, Saskia Biskup, Dennis Döcker, Dirk Schadendorf, Leticia Quintanilla-Martinez, Bernd J. Pichler, Manfred Kneilling, Ralph Mocikat, Martin Röcken
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ffeefb0c18174583b0c353a1c64a24f9
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spelling	oai:doaj.org-article:ffeefb0c18174583b0c353a1c64a24f92021-12-02T16:49:44ZCancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours10.1038/s41467-020-14987-62041-1723https://doaj.org/article/ffeefb0c18174583b0c353a1c64a24f92020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14987-6https://doaj.org/toc/2041-1723The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.Ellen BrennerBarbara F. SchörgFatima AhmetlićThomas WiederFranz Joachim HilkeNadine SimonChristopher SchroederGerman DemidovTanja RiedelBirgit FehrenbacherMartin SchallerAndrea ForschnerThomas EigentlerHeike NiessnerTobias SinnbergKatharina S. BöhmNadine HömbergHeidi BraumüllerDaniel DauchStefan ZwirnerLars ZenderDominik SonaniniAlbert GeishauserJürgen BauerMartin EichnerKatja J. JarickAndreas BeilhackSaskia BiskupDennis DöckerDirk SchadendorfLeticia Quintanilla-MartinezBernd J. PichlerManfred KneillingRalph MocikatMartin RöckenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ellen Brenner Barbara F. Schörg Fatima Ahmetlić Thomas Wieder Franz Joachim Hilke Nadine Simon Christopher Schroeder German Demidov Tanja Riedel Birgit Fehrenbacher Martin Schaller Andrea Forschner Thomas Eigentler Heike Niessner Tobias Sinnberg Katharina S. Böhm Nadine Hömberg Heidi Braumüller Daniel Dauch Stefan Zwirner Lars Zender Dominik Sonanini Albert Geishauser Jürgen Bauer Martin Eichner Katja J. Jarick Andreas Beilhack Saskia Biskup Dennis Döcker Dirk Schadendorf Leticia Quintanilla-Martinez Bernd J. Pichler Manfred Kneilling Ralph Mocikat Martin Röcken Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
description	The growth of cancer cells can be stably arrested by cytokine-induced senescence. Here, the authors show that cancers with defects in senescence-inducing cell cycle regulator pathways are resistant to immune checkpoint blockade.
format	article
author	Ellen Brenner Barbara F. Schörg Fatima Ahmetlić Thomas Wieder Franz Joachim Hilke Nadine Simon Christopher Schroeder German Demidov Tanja Riedel Birgit Fehrenbacher Martin Schaller Andrea Forschner Thomas Eigentler Heike Niessner Tobias Sinnberg Katharina S. Böhm Nadine Hömberg Heidi Braumüller Daniel Dauch Stefan Zwirner Lars Zender Dominik Sonanini Albert Geishauser Jürgen Bauer Martin Eichner Katja J. Jarick Andreas Beilhack Saskia Biskup Dennis Döcker Dirk Schadendorf Leticia Quintanilla-Martinez Bernd J. Pichler Manfred Kneilling Ralph Mocikat Martin Röcken
author_facet	Ellen Brenner Barbara F. Schörg Fatima Ahmetlić Thomas Wieder Franz Joachim Hilke Nadine Simon Christopher Schroeder German Demidov Tanja Riedel Birgit Fehrenbacher Martin Schaller Andrea Forschner Thomas Eigentler Heike Niessner Tobias Sinnberg Katharina S. Böhm Nadine Hömberg Heidi Braumüller Daniel Dauch Stefan Zwirner Lars Zender Dominik Sonanini Albert Geishauser Jürgen Bauer Martin Eichner Katja J. Jarick Andreas Beilhack Saskia Biskup Dennis Döcker Dirk Schadendorf Leticia Quintanilla-Martinez Bernd J. Pichler Manfred Kneilling Ralph Mocikat Martin Röcken
author_sort	Ellen Brenner
title	Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
title_short	Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
title_full	Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
title_fullStr	Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
title_full_unstemmed	Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
title_sort	cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ffeefb0c18174583b0c353a1c64a24f9
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Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

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