System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants

Purpose: to study the content changes of the antioxidants-chelators in dynamics of examining the persons exposed to the toxic substances. The cohort examination (with the interval of 4 years) of the employees exposed to the metallic mercury vapours, vinyl chloride (VC) and epichlorohydrin (EPCH) has...

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Autores principales:	I. V. Kudayeva, L. B. Masnavieva, L. A. Budarina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	antioxidants superoxide dismutase ceruloplasmin uric acid mercury vinyl chloride epichlorohydrin comjpensatory responses Science Q
Acceso en línea:	https://doaj.org/article/fff23e17f86846709dc8267f4867d5e6
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spelling	oai:doaj.org-article:fff23e17f86846709dc8267f4867d5e62021-11-23T06:14:27ZSystem responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants2541-94202587-9596https://doaj.org/article/fff23e17f86846709dc8267f4867d5e62013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1482https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Purpose: to study the content changes of the antioxidants-chelators in dynamics of examining the persons exposed to the toxic substances. The cohort examination (with the interval of 4 years) of the employees exposed to the metallic mercury vapours, vinyl chloride (VC) and epichlorohydrin (EPCH) has been performed. All the employees were divided into groups in dependence on the working period at the moment of the first examination. The content of ceruloplasmin (CP), the uric acid (UA) and the activity of superoxide dismutase (SOD) in the blood have been studied. Statistical processing the results was performed using the packet of applied programs "Statistica 6.0". The compensatory mechanisms of the responses were found to be different for the antioxidants-chelators in exposure to mercury and chlorine-bearing compounds. The exposure to mercury may promote the increase in the level of CP at the background of the decrease in the activity of SOD and have the stable character in time after 5 years of work and exposure to toxicant. In exposure to VC the analogous compensatory changes were found to begin after 10 years of production working careere and keep for the following 5 years of work. The further exposure to this toxicant may lead to the de-compensatory changes in the system of SOD-CP. The chronic exposure to EPCH may be followed by the increase in the level of UA, acquiring the pathogenetic character in 25 % of persons worked more than 10 years and the increase in the activity of SOD for the working period more than 15 years. The findings allow to conclude about the necessity of performing the timely preventive measures for the persons above. However, the trend and the time period of their initiation may be different. In the case of exposure to mercury the necessity of using the antioxidants (ascorbic acid, unsaturated fatty acids) may arise already after 5years of exposure to the toxicant. In exposure to vinyl chloride the analogous measures have to begin after 10 years of work. There to, using vitamin C is considered as purposeless. On the contrary, the preventive use of this antioxidant, beginning from 10 years of the production working period, is indicated for the employees exposed to epichlorohydrin.I. V. KudayevaL. B. MasnavievaL. A. BudarinaScientific Сentre for Family Health and Human Reproduction Problemsarticleantioxidantssuperoxide dismutaseceruloplasminuric acidmercuryvinyl chlorideepichlorohydrincomjpensatory responsesScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 22-26 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	antioxidants superoxide dismutase ceruloplasmin uric acid mercury vinyl chloride epichlorohydrin comjpensatory responses Science Q
spellingShingle	antioxidants superoxide dismutase ceruloplasmin uric acid mercury vinyl chloride epichlorohydrin comjpensatory responses Science Q I. V. Kudayeva L. B. Masnavieva L. A. Budarina System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
description	Purpose: to study the content changes of the antioxidants-chelators in dynamics of examining the persons exposed to the toxic substances. The cohort examination (with the interval of 4 years) of the employees exposed to the metallic mercury vapours, vinyl chloride (VC) and epichlorohydrin (EPCH) has been performed. All the employees were divided into groups in dependence on the working period at the moment of the first examination. The content of ceruloplasmin (CP), the uric acid (UA) and the activity of superoxide dismutase (SOD) in the blood have been studied. Statistical processing the results was performed using the packet of applied programs "Statistica 6.0". The compensatory mechanisms of the responses were found to be different for the antioxidants-chelators in exposure to mercury and chlorine-bearing compounds. The exposure to mercury may promote the increase in the level of CP at the background of the decrease in the activity of SOD and have the stable character in time after 5 years of work and exposure to toxicant. In exposure to VC the analogous compensatory changes were found to begin after 10 years of production working careere and keep for the following 5 years of work. The further exposure to this toxicant may lead to the de-compensatory changes in the system of SOD-CP. The chronic exposure to EPCH may be followed by the increase in the level of UA, acquiring the pathogenetic character in 25 % of persons worked more than 10 years and the increase in the activity of SOD for the working period more than 15 years. The findings allow to conclude about the necessity of performing the timely preventive measures for the persons above. However, the trend and the time period of their initiation may be different. In the case of exposure to mercury the necessity of using the antioxidants (ascorbic acid, unsaturated fatty acids) may arise already after 5years of exposure to the toxicant. In exposure to vinyl chloride the analogous measures have to begin after 10 years of work. There to, using vitamin C is considered as purposeless. On the contrary, the preventive use of this antioxidant, beginning from 10 years of the production working period, is indicated for the employees exposed to epichlorohydrin.
format	article
author	I. V. Kudayeva L. B. Masnavieva L. A. Budarina
author_facet	I. V. Kudayeva L. B. Masnavieva L. A. Budarina
author_sort	I. V. Kudayeva
title	System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
title_short	System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
title_full	System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
title_fullStr	System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
title_full_unstemmed	System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
title_sort	system responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/fff23e17f86846709dc8267f4867d5e6
work_keys_str_mv	AT ivkudayeva systemresponsivenessofantioxidantchelatorsinemployeesindynamicsofchronicexposuretoindustrialtoxicants AT lbmasnavieva systemresponsivenessofantioxidantchelatorsinemployeesindynamicsofchronicexposuretoindustrialtoxicants AT labudarina systemresponsivenessofantioxidantchelatorsinemployeesindynamicsofchronicexposuretoindustrialtoxicants
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System responsiveness of antioxidant chelators in employees in dynamics of chronic exposure to industrial toxicants

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