A Yersinia pestis tat mutant is attenuated in bubonic and small-aerosol pneumonic challenge models of infection but not as attenuated by intranasal challenge.

A Yersinia pestis tat mutant is attenuated in bubonic and small-aerosol pneumonic challenge models of infection but not as attenuated by intranasal challenge.

Bacterial proteins destined for the Tat pathway are folded before crossing the inner membrane and are typically identified by an N-terminal signal peptide containing a twin arginine motif. Translocation by the Tat pathway is dependent on the products of genes which encode proteins possessing the bin...

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Bibliographic Details
Main Authors: Joel Bozue, Christopher K Cote, Taylor Chance, Jeffrey Kugelman, Steven J Kern, Todd K Kijek, Amy Jenkins, Sherry Mou, Krishna Moody, David Fritz, Camenzind G Robinson, Todd Bell, Patricia Worsham
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/fff3a2746c114bfc99e7d70611c18ddf
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