The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and aut...

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Autores principales:	Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fff43c630ec94cdfb9d466891db5de81
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spelling	oai:doaj.org-article:fff43c630ec94cdfb9d466891db5de812021-12-02T15:07:49ZThe Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis10.1038/s41467-021-25145-x2041-1723https://doaj.org/article/fff43c630ec94cdfb9d466891db5de812021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25145-xhttps://doaj.org/toc/2041-1723Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.Ting YuanKarthika AnnamalaiShruti NaikBlaz LupseShirin GeravandiAnasua PalAleksandra DobrowolskiJaee GhawaliMarina RuhlandtKanaka Durga Devi GorrepatiZahra AziziDae-Sik LimKathrin MaedlerAmin ArdestaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
description	Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.
format	article
author	Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani
author_facet	Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani
author_sort	Ting Yuan
title	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_short	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_full	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_fullStr	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_full_unstemmed	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_sort	hippo kinase lats2 impairs pancreatic β-cell survival in diabetes through the mtorc1-autophagy axis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fff43c630ec94cdfb9d466891db5de81
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The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

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