Bcl-xL promotes metastasis independent of its anti-apoptotic activity

Bcl-xL is an anti-apoptotic protein that has also been implicated in metastasis. In this study, the authors show that nuclear Bcl-xL promotes metastasis by regulating TGFβ signaling, which is independent of the anti-apoptotic activity of Bcl-xL.

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Autores principales:	Soyoung Choi, Zhengming Chen, Laura H. Tang, Yuanzhang Fang, Sandra J. Shin, Nicole C. Panarelli, Yao-Tseng Chen, Yi Li, Xuejun Jiang, Yi-Chieh Nancy Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fff5c35ced354d01a213c99392b2ad36
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spelling	oai:doaj.org-article:fff5c35ced354d01a213c99392b2ad362021-12-02T16:49:41ZBcl-xL promotes metastasis independent of its anti-apoptotic activity10.1038/ncomms103842041-1723https://doaj.org/article/fff5c35ced354d01a213c99392b2ad362016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10384https://doaj.org/toc/2041-1723Bcl-xL is an anti-apoptotic protein that has also been implicated in metastasis. In this study, the authors show that nuclear Bcl-xL promotes metastasis by regulating TGFβ signaling, which is independent of the anti-apoptotic activity of Bcl-xL.Soyoung ChoiZhengming ChenLaura H. TangYuanzhang FangSandra J. ShinNicole C. PanarelliYao-Tseng ChenYi LiXuejun JiangYi-Chieh Nancy DuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soyoung Choi Zhengming Chen Laura H. Tang Yuanzhang Fang Sandra J. Shin Nicole C. Panarelli Yao-Tseng Chen Yi Li Xuejun Jiang Yi-Chieh Nancy Du Bcl-xL promotes metastasis independent of its anti-apoptotic activity
description	Bcl-xL is an anti-apoptotic protein that has also been implicated in metastasis. In this study, the authors show that nuclear Bcl-xL promotes metastasis by regulating TGFβ signaling, which is independent of the anti-apoptotic activity of Bcl-xL.
format	article
author	Soyoung Choi Zhengming Chen Laura H. Tang Yuanzhang Fang Sandra J. Shin Nicole C. Panarelli Yao-Tseng Chen Yi Li Xuejun Jiang Yi-Chieh Nancy Du
author_facet	Soyoung Choi Zhengming Chen Laura H. Tang Yuanzhang Fang Sandra J. Shin Nicole C. Panarelli Yao-Tseng Chen Yi Li Xuejun Jiang Yi-Chieh Nancy Du
author_sort	Soyoung Choi
title	Bcl-xL promotes metastasis independent of its anti-apoptotic activity
title_short	Bcl-xL promotes metastasis independent of its anti-apoptotic activity
title_full	Bcl-xL promotes metastasis independent of its anti-apoptotic activity
title_fullStr	Bcl-xL promotes metastasis independent of its anti-apoptotic activity
title_full_unstemmed	Bcl-xL promotes metastasis independent of its anti-apoptotic activity
title_sort	bcl-xl promotes metastasis independent of its anti-apoptotic activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fff5c35ced354d01a213c99392b2ad36
work_keys_str_mv	AT soyoungchoi bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT zhengmingchen bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT laurahtang bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT yuanzhangfang bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT sandrajshin bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT nicolecpanarelli bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT yaotsengchen bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT yili bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT xuejunjiang bclxlpromotesmetastasisindependentofitsantiapoptoticactivity AT yichiehnancydu bclxlpromotesmetastasisindependentofitsantiapoptoticactivity
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Bcl-xL promotes metastasis independent of its anti-apoptotic activity

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