Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Chimeric antigen receptor T cells in the clinic currently target cell-type-specific extracellular antigens on malignant cells. Here, authors engineer tumor-specific chimeric antigen receptor T cells that target human leukocyte antigen-presented neoantigens derived from mutant intracellular proteins.

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Autores principales:	Michael S. Hwang, Michelle S. Miller, Puchong Thirawatananond, Jacqueline Douglass, Katharine M. Wright, Emily Han-Chung Hsiue, Brian J. Mog, Tihitina Y. Aytenfisu, Michael B. Murphy, P. Aitana Azurmendi, Andrew D. Skora, Alexander H. Pearlman, Suman Paul, Sarah R. DiNapoli, Maximilian F. Konig, Chetan Bettegowda, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fff72ea490f640af8b0aeee032442ea5
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spelling	oai:doaj.org-article:fff72ea490f640af8b0aeee032442ea52021-12-02T14:55:15ZStructural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens10.1038/s41467-021-25605-42041-1723https://doaj.org/article/fff72ea490f640af8b0aeee032442ea52021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25605-4https://doaj.org/toc/2041-1723Chimeric antigen receptor T cells in the clinic currently target cell-type-specific extracellular antigens on malignant cells. Here, authors engineer tumor-specific chimeric antigen receptor T cells that target human leukocyte antigen-presented neoantigens derived from mutant intracellular proteins.Michael S. HwangMichelle S. MillerPuchong ThirawatananondJacqueline DouglassKatharine M. WrightEmily Han-Chung HsiueBrian J. MogTihitina Y. AytenfisuMichael B. MurphyP. Aitana AzurmendiAndrew D. SkoraAlexander H. PearlmanSuman PaulSarah R. DiNapoliMaximilian F. KonigChetan BettegowdaDrew M. PardollNickolas PapadopoulosKenneth W. KinzlerBert VogelsteinShibin ZhouSandra B. GabelliNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael S. Hwang Michelle S. Miller Puchong Thirawatananond Jacqueline Douglass Katharine M. Wright Emily Han-Chung Hsiue Brian J. Mog Tihitina Y. Aytenfisu Michael B. Murphy P. Aitana Azurmendi Andrew D. Skora Alexander H. Pearlman Suman Paul Sarah R. DiNapoli Maximilian F. Konig Chetan Bettegowda Drew M. Pardoll Nickolas Papadopoulos Kenneth W. Kinzler Bert Vogelstein Shibin Zhou Sandra B. Gabelli Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
description	Chimeric antigen receptor T cells in the clinic currently target cell-type-specific extracellular antigens on malignant cells. Here, authors engineer tumor-specific chimeric antigen receptor T cells that target human leukocyte antigen-presented neoantigens derived from mutant intracellular proteins.
format	article
author	Michael S. Hwang Michelle S. Miller Puchong Thirawatananond Jacqueline Douglass Katharine M. Wright Emily Han-Chung Hsiue Brian J. Mog Tihitina Y. Aytenfisu Michael B. Murphy P. Aitana Azurmendi Andrew D. Skora Alexander H. Pearlman Suman Paul Sarah R. DiNapoli Maximilian F. Konig Chetan Bettegowda Drew M. Pardoll Nickolas Papadopoulos Kenneth W. Kinzler Bert Vogelstein Shibin Zhou Sandra B. Gabelli
author_facet	Michael S. Hwang Michelle S. Miller Puchong Thirawatananond Jacqueline Douglass Katharine M. Wright Emily Han-Chung Hsiue Brian J. Mog Tihitina Y. Aytenfisu Michael B. Murphy P. Aitana Azurmendi Andrew D. Skora Alexander H. Pearlman Suman Paul Sarah R. DiNapoli Maximilian F. Konig Chetan Bettegowda Drew M. Pardoll Nickolas Papadopoulos Kenneth W. Kinzler Bert Vogelstein Shibin Zhou Sandra B. Gabelli
author_sort	Michael S. Hwang
title	Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
title_short	Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
title_full	Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
title_fullStr	Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
title_full_unstemmed	Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
title_sort	structural engineering of chimeric antigen receptors targeting hla-restricted neoantigens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fff72ea490f640af8b0aeee032442ea5
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Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

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