Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans

Abstract. Revianti S, Andriani D, Parisihni K, Wahjuningsih E, Widyastuti. 2020. Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans. Biodiversitas 21: 2977-2981. Aggressive pe...

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Autores principales:	SYAMSULINA REVIANTI, DWI ANDRIANI, KRISTANTI PARISIHNI, ENDAH WAHJUNINGSIH, WIDYASTUTI
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	aggregatibacter actinomycetemcomitans, anti-inflammatory, green microalgae, oral irrigation, nannochloropsis oculata Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fffaf19710f74cc4a105168185d0f9a3
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spelling	oai:doaj.org-article:fffaf19710f74cc4a105168185d0f9a32021-11-22T00:40:52ZEffectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans1412-033X2085-472210.13057/biodiv/d210714https://doaj.org/article/fffaf19710f74cc4a105168185d0f9a32020-06-01T00:00:00Zhttps://smujo.id/biodiv/article/view/5651https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Revianti S, Andriani D, Parisihni K, Wahjuningsih E, Widyastuti. 2020. Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans. Biodiversitas 21: 2977-2981. Aggressive periodontitis is strongly correlated with Aggregatibacter actinomycetemcomitans, a periodontopathic bacterium, which releases endotoxins and lipopolysaccharides (LPS). LPS acts as a stimulus to a variety of host cells that can promote the expression of pro-inflammatory cytokines, such as the tumor necrosis factor-? (TNF-?), in periodontal disease. The marine green microalga Nannochloropsis oculata has anti-inflammatory properties. This study aimed to examine the anti-inflammatory efficacy of oral irrigation with N. oculata extract against periodontitis induced by A. actinomycetemcomitans in a rat model. Twenty-four male Wistar rats were divided randomly into four groups (n = 6). First control group was without any treatment, the second to fourth groups were infected with A. actinomycetemcomitans and then orally irrigated with N. oculata extract at concentrations of 2.375%, 2.5%, and 2.625%. The mandibles of the euthanized rats were hemisected to measure the expression of TNF-?, interleukin-10 (IL-10, an anti-inflammatory cytokine), and osteoprotegerin (OPG) by immunohistochemistry. The first group (control) showed significantly higher expression of TNF-? and significantly lower expression of IL-10 and OPG compared to the other groups. Oral irrigation with N. oculata extracts reduced the expression of TNF-? and enhanced the expression of IL-10 and OPG in rats infected with A. actinomycetemcomitans. The effective concentration of N. oculata extract as an anti-inflammatory for oral irrigation was 2.375%.SYAMSULINA REVIANTIDWI ANDRIANIKRISTANTI PARISIHNIENDAH WAHJUNINGSIHWIDYASTUTIMBI & UNS Soloarticleaggregatibacter actinomycetemcomitans, anti-inflammatory, green microalgae, oral irrigation, nannochloropsis oculataBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aggregatibacter actinomycetemcomitans, anti-inflammatory, green microalgae, oral irrigation, nannochloropsis oculata Biology (General) QH301-705.5
spellingShingle	aggregatibacter actinomycetemcomitans, anti-inflammatory, green microalgae, oral irrigation, nannochloropsis oculata Biology (General) QH301-705.5 SYAMSULINA REVIANTI DWI ANDRIANI KRISTANTI PARISIHNI ENDAH WAHJUNINGSIH WIDYASTUTI Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
description	Abstract. Revianti S, Andriani D, Parisihni K, Wahjuningsih E, Widyastuti. 2020. Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans. Biodiversitas 21: 2977-2981. Aggressive periodontitis is strongly correlated with Aggregatibacter actinomycetemcomitans, a periodontopathic bacterium, which releases endotoxins and lipopolysaccharides (LPS). LPS acts as a stimulus to a variety of host cells that can promote the expression of pro-inflammatory cytokines, such as the tumor necrosis factor-? (TNF-?), in periodontal disease. The marine green microalga Nannochloropsis oculata has anti-inflammatory properties. This study aimed to examine the anti-inflammatory efficacy of oral irrigation with N. oculata extract against periodontitis induced by A. actinomycetemcomitans in a rat model. Twenty-four male Wistar rats were divided randomly into four groups (n = 6). First control group was without any treatment, the second to fourth groups were infected with A. actinomycetemcomitans and then orally irrigated with N. oculata extract at concentrations of 2.375%, 2.5%, and 2.625%. The mandibles of the euthanized rats were hemisected to measure the expression of TNF-?, interleukin-10 (IL-10, an anti-inflammatory cytokine), and osteoprotegerin (OPG) by immunohistochemistry. The first group (control) showed significantly higher expression of TNF-? and significantly lower expression of IL-10 and OPG compared to the other groups. Oral irrigation with N. oculata extracts reduced the expression of TNF-? and enhanced the expression of IL-10 and OPG in rats infected with A. actinomycetemcomitans. The effective concentration of N. oculata extract as an anti-inflammatory for oral irrigation was 2.375%.
format	article
author	SYAMSULINA REVIANTI DWI ANDRIANI KRISTANTI PARISIHNI ENDAH WAHJUNINGSIH WIDYASTUTI
author_facet	SYAMSULINA REVIANTI DWI ANDRIANI KRISTANTI PARISIHNI ENDAH WAHJUNINGSIH WIDYASTUTI
author_sort	SYAMSULINA REVIANTI
title	Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
title_short	Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
title_full	Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
title_fullStr	Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
title_full_unstemmed	Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans
title_sort	effectiveness of oral irrigation with an extract of green microalga nannochloropsis oculata as an anti-inflammatory in rats infected with aggregatibacter actinomycetemcomitans
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/fffaf19710f74cc4a105168185d0f9a3
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Effectiveness of oral irrigation with an extract of green microalga Nannochloropsis oculata as an anti-inflammatory in rats infected with Aggregatibacter actinomycetemcomitans

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