Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.

Heterogeneous classes of neurons are present in the spinal cord and are essential for its function. Expression patterns of transcription factors in neural progenitor cells determine neuron subtypes during development. Nkx2.2 is expressed in the progenitor cell pool located just ventrally to the Olig...

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Autores principales:	Hitoshi Gotoh, Katsuhiko Ono, Tadashi Nomura, Hirohide Takebayashi, Hidekiyo Harada, Harukazu Nakamura, Kazuhiro Ikenaka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fffe1e40e6374a548be566aae9f93bda
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spelling	oai:doaj.org-article:fffe1e40e6374a548be566aae9f93bda2021-11-18T08:04:50ZNkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.1932-620310.1371/journal.pone.0051581https://doaj.org/article/fffe1e40e6374a548be566aae9f93bda2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284718/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Heterogeneous classes of neurons are present in the spinal cord and are essential for its function. Expression patterns of transcription factors in neural progenitor cells determine neuron subtypes during development. Nkx2.2 is expressed in the progenitor cell pool located just ventrally to the Olig2-positive pool and is indispensable for V3 interneuron generation in the spinal cord and also for visceral motoneuron generation in the hindbrain. However, whether Nkx2.2-positive progenitor cells generate diverse classes of neuron is not fully understood. Using a chick lineage tracing method in a genetically-defined manner, we found that Nkx2.2-expressing progenitor cells differentiate into general visceral motoneurons as well as sim1-positive V3 interneurons. Surprisingly, we further observed that Nkx2.2-expressing progenitors differentiate into somatic motoneuron. Our findings suggest that the different classes of motoneurons are derived from more complex sources than were previously expected in the chick spinal cord.Hitoshi GotohKatsuhiko OnoTadashi NomuraHirohide TakebayashiHidekiyo HaradaHarukazu NakamuraKazuhiro IkenakaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51581 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hitoshi Gotoh Katsuhiko Ono Tadashi Nomura Hirohide Takebayashi Hidekiyo Harada Harukazu Nakamura Kazuhiro Ikenaka Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
description	Heterogeneous classes of neurons are present in the spinal cord and are essential for its function. Expression patterns of transcription factors in neural progenitor cells determine neuron subtypes during development. Nkx2.2 is expressed in the progenitor cell pool located just ventrally to the Olig2-positive pool and is indispensable for V3 interneuron generation in the spinal cord and also for visceral motoneuron generation in the hindbrain. However, whether Nkx2.2-positive progenitor cells generate diverse classes of neuron is not fully understood. Using a chick lineage tracing method in a genetically-defined manner, we found that Nkx2.2-expressing progenitor cells differentiate into general visceral motoneurons as well as sim1-positive V3 interneurons. Surprisingly, we further observed that Nkx2.2-expressing progenitors differentiate into somatic motoneuron. Our findings suggest that the different classes of motoneurons are derived from more complex sources than were previously expected in the chick spinal cord.
format	article
author	Hitoshi Gotoh Katsuhiko Ono Tadashi Nomura Hirohide Takebayashi Hidekiyo Harada Harukazu Nakamura Kazuhiro Ikenaka
author_facet	Hitoshi Gotoh Katsuhiko Ono Tadashi Nomura Hirohide Takebayashi Hidekiyo Harada Harukazu Nakamura Kazuhiro Ikenaka
author_sort	Hitoshi Gotoh
title	Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
title_short	Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
title_full	Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
title_fullStr	Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
title_full_unstemmed	Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
title_sort	nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fffe1e40e6374a548be566aae9f93bda
work_keys_str_mv	AT hitoshigotoh nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT katsuhikoono nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT tadashinomura nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT hirohidetakebayashi nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT hidekiyoharada nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT harukazunakamura nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord AT kazuhiroikenaka nkx22progenitorsgeneratesomaticmotoneuronsinthechickspinalcord
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Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.

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