Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interaction for efficient and accurate translation.
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Nature Portfolio
2018
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oai:doaj.org-article:ffffbc1b3a5340bdb59935247e94c0d42021-12-02T14:40:09ZTranslation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions10.1038/s41467-018-07321-82041-1723https://doaj.org/article/ffffbc1b3a5340bdb59935247e94c0d42018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07321-8https://doaj.org/toc/2041-1723The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interaction for efficient and accurate translation.Thomas Philipp HoernesKlaus FaserlMichael Andreas JuenJohannes KremserCatherina GasserElisabeth FuchsXinying ShiAaron SiewertHerbert LindnerChristoph KreutzRonald MicuraSimpson JosephClaudia HöbartnerEric WesthofAlexander HüttenhoferMatthias David ErlacherNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Thomas Philipp Hoernes Klaus Faserl Michael Andreas Juen Johannes Kremser Catherina Gasser Elisabeth Fuchs Xinying Shi Aaron Siewert Herbert Lindner Christoph Kreutz Ronald Micura Simpson Joseph Claudia Höbartner Eric Westhof Alexander Hüttenhofer Matthias David Erlacher Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| description |
The recognition of the mRNA codon by the tRNA anticodon is crucial for protein synthesis. Here the authors introduce non-standard nucleotides in bacterial and eukaryotic mRNA to reveal the minimal hydrogen bond requirement of codon-anticodon interaction for efficient and accurate translation. |
| format |
article |
| author |
Thomas Philipp Hoernes Klaus Faserl Michael Andreas Juen Johannes Kremser Catherina Gasser Elisabeth Fuchs Xinying Shi Aaron Siewert Herbert Lindner Christoph Kreutz Ronald Micura Simpson Joseph Claudia Höbartner Eric Westhof Alexander Hüttenhofer Matthias David Erlacher |
| author_facet |
Thomas Philipp Hoernes Klaus Faserl Michael Andreas Juen Johannes Kremser Catherina Gasser Elisabeth Fuchs Xinying Shi Aaron Siewert Herbert Lindner Christoph Kreutz Ronald Micura Simpson Joseph Claudia Höbartner Eric Westhof Alexander Hüttenhofer Matthias David Erlacher |
| author_sort |
Thomas Philipp Hoernes |
| title |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| title_short |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| title_full |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| title_fullStr |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| title_full_unstemmed |
Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| title_sort |
translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ffffbc1b3a5340bdb59935247e94c0d4 |
| work_keys_str_mv |
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| _version_ |
1718390456090361856 |