Superantígenos y su rol en enfermedades infecciosas

The role of superantigens in infectious diseases Exogenous antigens are presented to T lymphocytes through a mechanism that ensures a high recognition specificity. On the other hand, recently described superantigens are particles that do not follow the processing or presentation route and do not bi...

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Autor principal:	Santolaya de P,María Elena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1998
Materias:	Superantigens Receptors, antigen, T-cell, alpha-beta Infections diseases Bacterial toxins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871998000700014
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spelling	oai:scielo:S0034-988719980007000141999-06-15Superantígenos y su rol en enfermedades infecciosasSantolaya de P,María Elena Superantigens Receptors, antigen, T-cell, alpha-beta Infections diseases Bacterial toxins The role of superantigens in infectious diseases Exogenous antigens are presented to T lymphocytes through a mechanism that ensures a high recognition specificity. On the other hand, recently described superantigens are particles that do not follow the processing or presentation route and do not bind to a specific region of T lymphocyte receptors, as conventional antigens. These particles bind to a large number of T lymphocytes, generating a disproportionate and unspecific immune response. Two types of superantigens have been described. Endogenous superantigens, that are transported in the host genoma, and that are involved in clonal depletion and immunological tolerance phenomena. Exogenous superantigens, mostly bacterial toxins, are involved in several diseases. There is evidence that these antigens participate in diseases such as Kawasaki disease, toxic shock caused by Staphylococcus aureus, rheumatoid arthritis, HIV infection and Streptococcus pyogenes infectionsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.126 n.7 19981998-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871998000700014es10.4067/S0034-98871998000700014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Superantigens Receptors, antigen, T-cell, alpha-beta Infections diseases Bacterial toxins
spellingShingle	Superantigens Receptors, antigen, T-cell, alpha-beta Infections diseases Bacterial toxins Santolaya de P,María Elena Superantígenos y su rol en enfermedades infecciosas
description	The role of superantigens in infectious diseases Exogenous antigens are presented to T lymphocytes through a mechanism that ensures a high recognition specificity. On the other hand, recently described superantigens are particles that do not follow the processing or presentation route and do not bind to a specific region of T lymphocyte receptors, as conventional antigens. These particles bind to a large number of T lymphocytes, generating a disproportionate and unspecific immune response. Two types of superantigens have been described. Endogenous superantigens, that are transported in the host genoma, and that are involved in clonal depletion and immunological tolerance phenomena. Exogenous superantigens, mostly bacterial toxins, are involved in several diseases. There is evidence that these antigens participate in diseases such as Kawasaki disease, toxic shock caused by Staphylococcus aureus, rheumatoid arthritis, HIV infection and Streptococcus pyogenes infections
author	Santolaya de P,María Elena
author_facet	Santolaya de P,María Elena
author_sort	Santolaya de P,María Elena
title	Superantígenos y su rol en enfermedades infecciosas
title_short	Superantígenos y su rol en enfermedades infecciosas
title_full	Superantígenos y su rol en enfermedades infecciosas
title_fullStr	Superantígenos y su rol en enfermedades infecciosas
title_full_unstemmed	Superantígenos y su rol en enfermedades infecciosas
title_sort	superantígenos y su rol en enfermedades infecciosas
publisher	Sociedad Médica de Santiago
publishDate	1998
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871998000700014
work_keys_str_mv	AT santolayadepmariaelena superantigenosysurolenenfermedadesinfecciosas
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Superantígenos y su rol en enfermedades infecciosas

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