Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis

Background: When hypertension treatment does not achieve the expected reduction in blood pressure levels, experts recommend increasing the dose of the initially used drug or the addition of a new medication. Aim: To compare the efficacy of increasing doses of losartan or the addition of hydrochlorot...

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Autores principales:	Fasce H,Eduardo, Wagemann B,Heidi
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Antihypertensive agents Hydrochlorothiazide Hypertension Losartan
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000800004
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spelling	oai:scielo:S0034-988719990008000042005-11-14Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosisFasce H,EduardoWagemann B,Heidi Antihypertensive agents Hydrochlorothiazide Hypertension Losartan Background: When hypertension treatment does not achieve the expected reduction in blood pressure levels, experts recommend increasing the dose of the initially used drug or the addition of a new medication. Aim: To compare the efficacy of increasing doses of losartan or the addition of hydrochlorothiazide to achieve adequate blood pressure levels in patients with hypertension. Patients and methods: Seventy three patients aged 64.4 ± 5.3 years, with stage 1 or 2 essential hypertension were studied. If after four weeks of treatment with losartan 50 mg od, blood pressure levels were still high, the dose was increased to 100 mg od. After four weeks with this new schedule, the treatment was switched to losartan 50 mg and hydrochlorothiazide 12.5 mg for another four weeks. Results: Thirty seven patients normalized blood pressure with losartan 50 mg od. Of the 36 patients that did not respond, 69% achieved a normal blood pressure with losartan 100 mg od and 81% did so with the combination of losartan and hydrochlorothiazide. Combination therapy resulted in a better blood pressure lowering than monotherapy (33.2 ± 3.2 and 29.5 ± 3.4 mm Hg for systolic blood pressure respectively, 16.4 ± 3.2 and 13.2 ± 3.4 mm Hg for diastolic blood pressure, p <0.05). No changes in blood glucose, total and HDL cholesterol, triglycerides, urea nitrogen and uric acid were observed with the combination therapy. Conclusions: In this group of patients, combination therapy achieved better blood pressure levels than monotherapy in high doses.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.8 19991999-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000800004es10.4067/S0034-98871999000800004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antihypertensive agents Hydrochlorothiazide Hypertension Losartan
spellingShingle	Antihypertensive agents Hydrochlorothiazide Hypertension Losartan Fasce H,Eduardo Wagemann B,Heidi Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
description	Background: When hypertension treatment does not achieve the expected reduction in blood pressure levels, experts recommend increasing the dose of the initially used drug or the addition of a new medication. Aim: To compare the efficacy of increasing doses of losartan or the addition of hydrochlorothiazide to achieve adequate blood pressure levels in patients with hypertension. Patients and methods: Seventy three patients aged 64.4 ± 5.3 years, with stage 1 or 2 essential hypertension were studied. If after four weeks of treatment with losartan 50 mg od, blood pressure levels were still high, the dose was increased to 100 mg od. After four weeks with this new schedule, the treatment was switched to losartan 50 mg and hydrochlorothiazide 12.5 mg for another four weeks. Results: Thirty seven patients normalized blood pressure with losartan 50 mg od. Of the 36 patients that did not respond, 69% achieved a normal blood pressure with losartan 100 mg od and 81% did so with the combination of losartan and hydrochlorothiazide. Combination therapy resulted in a better blood pressure lowering than monotherapy (33.2 ± 3.2 and 29.5 ± 3.4 mm Hg for systolic blood pressure respectively, 16.4 ± 3.2 and 13.2 ± 3.4 mm Hg for diastolic blood pressure, p <0.05). No changes in blood glucose, total and HDL cholesterol, triglycerides, urea nitrogen and uric acid were observed with the combination therapy. Conclusions: In this group of patients, combination therapy achieved better blood pressure levels than monotherapy in high doses.
author	Fasce H,Eduardo Wagemann B,Heidi
author_facet	Fasce H,Eduardo Wagemann B,Heidi
author_sort	Fasce H,Eduardo
title	Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
title_short	Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
title_full	Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
title_fullStr	Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
title_full_unstemmed	Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
title_sort	comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000800004
work_keys_str_mv	AT fasceheduardo comparaciondelaeficaciaantihipertensivademonoterapiaendosiscrecientesversusterapiaasociadaenbajasdosis AT wagemannbheidi comparaciondelaeficaciaantihipertensivademonoterapiaendosiscrecientesversusterapiaasociadaenbajasdosis
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Comparación de la eficacia antihipertensiva de monoterapia en dosis crecientes versus terapia asociada en bajas dosis

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