Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa

Background: DNA typing in forensic analysis is a useful tool to analyze paternity due to its high discrimination power. Aim: To report the experience of Servicio Medico Legal in Santiago, resolving cases of dubious paternity. Subjects and methods: Four highly polymorphic loci, amplified by polymeras...

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Autores principales:	Jorquera G,Hugo, Acuña P,Mónica, Cifuentes O,Lucía, Aguirre M,Eugenia, Moreno Ch,Fabián
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	DNA fingerprinting Genetics, medical Paternity Polymerase chain reaction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000900004
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spelling	oai:scielo:S0034-988719990009000041999-12-13Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasaJorquera G,HugoAcuña P,MónicaCifuentes O,LucíaAguirre M,EugeniaMoreno Ch,Fabián DNA fingerprinting Genetics, medical Paternity Polymerase chain reaction Background: DNA typing in forensic analysis is a useful tool to analyze paternity due to its high discrimination power. Aim: To report the experience of Servicio Medico Legal in Santiago, resolving cases of dubious paternity. Subjects and methods: Four highly polymorphic loci, amplified by polymerase chain reactions, were analyzed in 153 cases of uncertain paternity. The paternity index was calculated for each case. Results: The four genetic markers analyzed provided an exclusion probability of 0.933 for the general population in Santiago. Thirty seven cases were excluded as parents. In 31 cases, the paternity index ranged from 19 to 100, considered as probable paternity and 77 cases had an index of over 100, considered as almost certain paternity. Eight cases had an index between 0.5 and 19, considered as inconclusive. All loci met Hardy-Weinberg expectations and their frequencies were similar to other data from people living in Santiago. Conclusions: The use of these genetic markers proved to be very useful, reliable and with a high exclusion power for paternity analysisinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.9 19991999-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000900004es10.4067/S0034-98871999000900004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	DNA fingerprinting Genetics, medical Paternity Polymerase chain reaction
spellingShingle	DNA fingerprinting Genetics, medical Paternity Polymerase chain reaction Jorquera G,Hugo Acuña P,Mónica Cifuentes O,Lucía Aguirre M,Eugenia Moreno Ch,Fabián Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
description	Background: DNA typing in forensic analysis is a useful tool to analyze paternity due to its high discrimination power. Aim: To report the experience of Servicio Medico Legal in Santiago, resolving cases of dubious paternity. Subjects and methods: Four highly polymorphic loci, amplified by polymerase chain reactions, were analyzed in 153 cases of uncertain paternity. The paternity index was calculated for each case. Results: The four genetic markers analyzed provided an exclusion probability of 0.933 for the general population in Santiago. Thirty seven cases were excluded as parents. In 31 cases, the paternity index ranged from 19 to 100, considered as probable paternity and 77 cases had an index of over 100, considered as almost certain paternity. Eight cases had an index between 0.5 and 19, considered as inconclusive. All loci met Hardy-Weinberg expectations and their frequencies were similar to other data from people living in Santiago. Conclusions: The use of these genetic markers proved to be very useful, reliable and with a high exclusion power for paternity analysis
author	Jorquera G,Hugo Acuña P,Mónica Cifuentes O,Lucía Aguirre M,Eugenia Moreno Ch,Fabián
author_facet	Jorquera G,Hugo Acuña P,Mónica Cifuentes O,Lucía Aguirre M,Eugenia Moreno Ch,Fabián
author_sort	Jorquera G,Hugo
title	Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
title_short	Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
title_full	Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
title_fullStr	Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
title_full_unstemmed	Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa
title_sort	análisis de paternidad utilizando cuatro marcadores de dna amplificados mediante la reacción en cadena de polimerasa
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000900004
work_keys_str_mv	AT jorqueraghugo analisisdepaternidadutilizandocuatromarcadoresdednaamplificadosmediantelareaccionencadenadepolimerasa AT acunapmonica analisisdepaternidadutilizandocuatromarcadoresdednaamplificadosmediantelareaccionencadenadepolimerasa AT cifuentesolucia analisisdepaternidadutilizandocuatromarcadoresdednaamplificadosmediantelareaccionencadenadepolimerasa AT aguirremeugenia analisisdepaternidadutilizandocuatromarcadoresdednaamplificadosmediantelareaccionencadenadepolimerasa AT morenochfabian analisisdepaternidadutilizandocuatromarcadoresdednaamplificadosmediantelareaccionencadenadepolimerasa
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Análisis de paternidad utilizando cuatro marcadores de DNA amplificados mediante la reacción en cadena de polimerasa

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