Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile

Background: Most of the studies of HIV-1 infection in South America have been limited to Brazil and little is known about the viral variants that are causing disease elsewhere in the continent. Aim: To determine the characteristics of the viral variants present in Chile as well as patterns of viral...

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Autores principales:	Pérez C,Carlos, Vial C,Pablo, Dorman,Karin S, Wang,Greg, Wang,Guangqiang, Abarca V,Katia, Sinsheimer,Janet S, Kaplan,Andrew H
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Acquired immunodeficiency syndrome AIDS serodiagnosis HIV-1 Virology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100002
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spelling	oai:scielo:S0034-988719990011000022005-11-23Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, ChilePérez C,CarlosVial C,PabloDorman,Karin SWang,GregWang,GuangqiangAbarca V,KatiaSinsheimer,Janet SKaplan,Andrew H Acquired immunodeficiency syndrome AIDS serodiagnosis HIV-1 Virology Background: Most of the studies of HIV-1 infection in South America have been limited to Brazil and little is known about the viral variants that are causing disease elsewhere in the continent. Aim: To determine the characteristics of the viral variants present in Chile as well as patterns of viral transmission. Material and methods: Viral sequences were obtained from 21 HIV-1 infected people from Santiago, Chile who were infected either via sexual contact or intravenous drug use. Cloned sequences obtained from both the third variable and conserved regions of the envelope as well as the viral protease were evaluated. Results: We found only clade B subtype viruses in Santiago. An evaluation of the envelope gene revealed no evidence that the sequences were monophyletic by risk group. A number of the protease sequences were predicted to encode amino acid substitutions commonly found during selection for protease inhibitor resistance. Conclusions: The HIV-1 strains studied in Chile, belong to the subtype B. There is no molecular evidence of separate introductions of the virus into the different risk groups. A number of substitutions in the protease gene that may confer resistance to protease inhibitors were found in patients with no previous exposure to this class of drugs.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.11 19991999-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100002es10.4067/S0034-98871999001100002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acquired immunodeficiency syndrome AIDS serodiagnosis HIV-1 Virology
spellingShingle	Acquired immunodeficiency syndrome AIDS serodiagnosis HIV-1 Virology Pérez C,Carlos Vial C,Pablo Dorman,Karin S Wang,Greg Wang,Guangqiang Abarca V,Katia Sinsheimer,Janet S Kaplan,Andrew H Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
description	Background: Most of the studies of HIV-1 infection in South America have been limited to Brazil and little is known about the viral variants that are causing disease elsewhere in the continent. Aim: To determine the characteristics of the viral variants present in Chile as well as patterns of viral transmission. Material and methods: Viral sequences were obtained from 21 HIV-1 infected people from Santiago, Chile who were infected either via sexual contact or intravenous drug use. Cloned sequences obtained from both the third variable and conserved regions of the envelope as well as the viral protease were evaluated. Results: We found only clade B subtype viruses in Santiago. An evaluation of the envelope gene revealed no evidence that the sequences were monophyletic by risk group. A number of the protease sequences were predicted to encode amino acid substitutions commonly found during selection for protease inhibitor resistance. Conclusions: The HIV-1 strains studied in Chile, belong to the subtype B. There is no molecular evidence of separate introductions of the virus into the different risk groups. A number of substitutions in the protease gene that may confer resistance to protease inhibitors were found in patients with no previous exposure to this class of drugs.
author	Pérez C,Carlos Vial C,Pablo Dorman,Karin S Wang,Greg Wang,Guangqiang Abarca V,Katia Sinsheimer,Janet S Kaplan,Andrew H
author_facet	Pérez C,Carlos Vial C,Pablo Dorman,Karin S Wang,Greg Wang,Guangqiang Abarca V,Katia Sinsheimer,Janet S Kaplan,Andrew H
author_sort	Pérez C,Carlos
title	Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
title_short	Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
title_full	Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
title_fullStr	Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
title_full_unstemmed	Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile
title_sort	epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en santiago, chile
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100002
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Epidemiología molecular del virus de inmunodeficiencia humana tipo 1 en Santiago, Chile

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