Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles

Background: The diagnosis of patients with short segments of intestinal metaplasia in the distal esophagus, has increased in recent years. Aim: To assess the clinical, pathological and functional features of patients with esophageal intestinal metaplasia. Patients and methods: A prospective study wa...

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Autores principales:	Csendes J,Attila, Burdiles P,Patricio, Smok S,Gladys, Rojas C,Jorge, Flores M,Noé, Domic P,Sergio, Quiroz G,Juan, Henríquez G,Ana
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Barret esophagus Gastroesophageal reflux Esophageal motility disorders
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100005
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spelling	oai:scielo:S0034-988719990011000052005-11-23Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controlesCsendes J,AttilaBurdiles P,PatricioSmok S,GladysRojas C,JorgeFlores M,NoéDomic P,SergioQuiroz G,JuanHenríquez G,Ana Barret esophagus Gastroesophageal reflux Esophageal motility disorders Background: The diagnosis of patients with short segments of intestinal metaplasia in the distal esophagus, has increased in recent years. Aim: To assess the clinical, pathological and functional features of patients with esophageal intestinal metaplasia. Patients and methods: A prospective study was performed in 95 control subjects, 115 patients with cardial intestinal metaplasia and 89 patients with short Barret esophagus with intestinal metaplasia. All had clinical and endoscopic assessments, esophageal manometry and determination of 24 h esophageal exposure to acid and duodenal content. Results: Control patients were younger and, in this group, the pathological findings in the mucosa distal to the squamous-columnar change, showed a preponderance of fundic over cardial mucosa. In patients with intestinal metaplasia and short Barret esophagus, there was only cardial mucosa, that is the place where intestinal metaplasia implants. Low grade dysplasia was only seen in the presence of intestinal metaplasia. Gastroesophageal sphincter pressure decreased and gastric and duodenal reflux increased along with increases in the extension of intestinal metaplasia. Conclusions: These findings confirm the need to obtain multiple biopsies from the squamous-columnar mucosal junction in all patients with gastroesophageal reflux symptoms, for the detection of early pathological changes of Barret esophagus and eventual dysplasia.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.11 19991999-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100005es10.4067/S0034-98871999001100005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Barret esophagus Gastroesophageal reflux Esophageal motility disorders
spellingShingle	Barret esophagus Gastroesophageal reflux Esophageal motility disorders Csendes J,Attila Burdiles P,Patricio Smok S,Gladys Rojas C,Jorge Flores M,Noé Domic P,Sergio Quiroz G,Juan Henríquez G,Ana Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
description	Background: The diagnosis of patients with short segments of intestinal metaplasia in the distal esophagus, has increased in recent years. Aim: To assess the clinical, pathological and functional features of patients with esophageal intestinal metaplasia. Patients and methods: A prospective study was performed in 95 control subjects, 115 patients with cardial intestinal metaplasia and 89 patients with short Barret esophagus with intestinal metaplasia. All had clinical and endoscopic assessments, esophageal manometry and determination of 24 h esophageal exposure to acid and duodenal content. Results: Control patients were younger and, in this group, the pathological findings in the mucosa distal to the squamous-columnar change, showed a preponderance of fundic over cardial mucosa. In patients with intestinal metaplasia and short Barret esophagus, there was only cardial mucosa, that is the place where intestinal metaplasia implants. Low grade dysplasia was only seen in the presence of intestinal metaplasia. Gastroesophageal sphincter pressure decreased and gastric and duodenal reflux increased along with increases in the extension of intestinal metaplasia. Conclusions: These findings confirm the need to obtain multiple biopsies from the squamous-columnar mucosal junction in all patients with gastroesophageal reflux symptoms, for the detection of early pathological changes of Barret esophagus and eventual dysplasia.
author	Csendes J,Attila Burdiles P,Patricio Smok S,Gladys Rojas C,Jorge Flores M,Noé Domic P,Sergio Quiroz G,Juan Henríquez G,Ana
author_facet	Csendes J,Attila Burdiles P,Patricio Smok S,Gladys Rojas C,Jorge Flores M,Noé Domic P,Sergio Quiroz G,Juan Henríquez G,Ana
author_sort	Csendes J,Attila
title	Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
title_short	Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
title_full	Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
title_fullStr	Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
title_full_unstemmed	Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles
title_sort	hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de barrett corto, comparados con controles
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100005
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Hallazgos clínicos, endoscópicos y magnitud del reflujo de contenido gástrico y duodenal en pacientes con metaplasia intestinal cardial y esófago de Barrett corto, comparados con controles

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