Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente

Background: Malignant hepatic tumors (Mht) are rare in children. Among them hepatoblastoma (HB) is the most common. Aim: To report the results of the multidisciplinary management in 6 consecutive children: five HB and one metastatic Wilms tumor (MWT). Patients and methods: The mean age of patients w...

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Autores principales:	Herrera V,José Miguel, Barriga C,Francisco, Harris D,Paul, Ronco M,Ricardo, García B,Cristián, Rossi F,Ricardo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Alpha-fetoproteins Chemotherapy, adjuvant, Hepatectomy Hepatoblastoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100009
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spelling	oai:scielo:S0034-988719990011000092005-11-23Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional recienteHerrera V,José MiguelBarriga C,FranciscoHarris D,PaulRonco M,RicardoGarcía B,CristiánRossi F,Ricardo Alpha-fetoproteins Chemotherapy, adjuvant, Hepatectomy Hepatoblastoma Background: Malignant hepatic tumors (Mht) are rare in children. Among them hepatoblastoma (HB) is the most common. Aim: To report the results of the multidisciplinary management in 6 consecutive children: five HB and one metastatic Wilms tumor (MWT). Patients and methods: The mean age of patients was 42 months. All HB patients had elevated serum alfafetoprotein (median 150,000 ng/ml). All patients received preoperative chemotherapy: HB patients received carboplatin/doxorrubicin alternating with cisplatin, and the MWT patient, vincristine alone. Surgery included two formal right and two formal left hepatectomies, one extensive central resection with partial left segmentectomy, and one lateral segmentectomy. Extracorporeal circulation was used in the child with atrial involvement. All patients received postoperative chemotherapy. Results: All tumors had variable regresion on preoperative chemotherapy. Complete resection with negative margins was achieved in all patients. The degree of tumor necrosis on histology ranged from 60% to 90%. Alfafetoprotein levels fell to under 10 ng/ml in all HB cases, one to three months after surgery. All patients survive free of disease at a median follow up of 19 months. Conclusion: A multidisciplinary approach including the well timed used of chemotherapy and surgery is highly effective in the management of pediatric malignant tumors.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.11 19991999-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100009es10.4067/S0034-98871999001100009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alpha-fetoproteins Chemotherapy, adjuvant, Hepatectomy Hepatoblastoma
spellingShingle	Alpha-fetoproteins Chemotherapy, adjuvant, Hepatectomy Hepatoblastoma Herrera V,José Miguel Barriga C,Francisco Harris D,Paul Ronco M,Ricardo García B,Cristián Rossi F,Ricardo Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
description	Background: Malignant hepatic tumors (Mht) are rare in children. Among them hepatoblastoma (HB) is the most common. Aim: To report the results of the multidisciplinary management in 6 consecutive children: five HB and one metastatic Wilms tumor (MWT). Patients and methods: The mean age of patients was 42 months. All HB patients had elevated serum alfafetoprotein (median 150,000 ng/ml). All patients received preoperative chemotherapy: HB patients received carboplatin/doxorrubicin alternating with cisplatin, and the MWT patient, vincristine alone. Surgery included two formal right and two formal left hepatectomies, one extensive central resection with partial left segmentectomy, and one lateral segmentectomy. Extracorporeal circulation was used in the child with atrial involvement. All patients received postoperative chemotherapy. Results: All tumors had variable regresion on preoperative chemotherapy. Complete resection with negative margins was achieved in all patients. The degree of tumor necrosis on histology ranged from 60% to 90%. Alfafetoprotein levels fell to under 10 ng/ml in all HB cases, one to three months after surgery. All patients survive free of disease at a median follow up of 19 months. Conclusion: A multidisciplinary approach including the well timed used of chemotherapy and surgery is highly effective in the management of pediatric malignant tumors.
author	Herrera V,José Miguel Barriga C,Francisco Harris D,Paul Ronco M,Ricardo García B,Cristián Rossi F,Ricardo
author_facet	Herrera V,José Miguel Barriga C,Francisco Harris D,Paul Ronco M,Ricardo García B,Cristián Rossi F,Ricardo
author_sort	Herrera V,José Miguel
title	Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
title_short	Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
title_full	Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
title_fullStr	Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
title_full_unstemmed	Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
title_sort	manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100009
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Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente

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