Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes

Background: Tourettes syndrome is a childhood-onset hereditary neurobehavioural disorder believed to occur without geographical restrictions. Although there have been reports of this disorder worldwide just a few are from Latin America. Aim: To report a preliminary experience with a series of 70 pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Miranda C,Marcelo, Menéndez G,Pedro, David G,Perla, Troncoso Sch,Mónica, Hernández Ch,Marta, Chaná C,Pedro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Tourette Syndrome Tics, Obsessive-compulsive disorder Basal ganglia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200010
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98871999001200010
record_format	dspace
spelling	oai:scielo:S0034-988719990012000102000-04-05Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientesMiranda C,MarceloMenéndez G,PedroDavid G,PerlaTroncoso Sch,MónicaHernández Ch,MartaChaná C,Pedro Tourette Syndrome Tics, Obsessive-compulsive disorder Basal ganglia Background: Tourettes syndrome is a childhood-onset hereditary neurobehavioural disorder believed to occur without geographical restrictions. Although there have been reports of this disorder worldwide just a few are from Latin America. Aim: To report a preliminary experience with a series of 70 patients and to review recent advances in this disorder. Patients and Method: We reviewed patients seen in pediatric and adult neurological clinics in Santiago, Chile, all of whom fulfilled clinical diagnostic criteria for Tourette Syndrome. Results: Seventy patients were studied, 54 males (77.1%) and 16 females (22.8%), their mean age at first evaluation was 13.6 years (range 2-46). The mean age of onset of symptoms was 6.4 (range 2-20), the mean time of follow-up was 3 years. Fifty-eight patients showed simple motor tics (blinking, facial grimacing, shoulder shrugging), whereas dystonic tics like head jerking were seen in 38 patients, torticollis in 6 and oculogyric movements in 2. Complex motor tics like jumping, antics, trunk bending and head shaking were present in 16 subjects. Vocal tics were predominantly of the simple type: sniffing, throat clearing, blowing, and whistling. Complex vocal tics were seen in 12 patients, five cases showed palilalia, 3 echolalia and only six displayed coprolalia (8.5%). Tics were of mild to moderate severity in most patients. Obsessive-compulsive disorder was observed in 22.8% and attention deficit and hyperactivity disorder were present in 35.7%. Forty-five patients (64.2%) had a first degree relative with tics, nine patients (12.8%) had a family history of obsessive-compulsive disorder. The current evidence involving desinhibition of cortico-striatum-thalamic-cortical neuronal circuits in the pathogenesis of this disorder is analyzed. Conclusion: Our report supports the recognized clinical homogeneity and genetical basis of Tourettes syndrome regardless of geographical region and ethnic origin.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.12 19991999-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200010es10.4067/S0034-98871999001200010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Tourette Syndrome Tics, Obsessive-compulsive disorder Basal ganglia
spellingShingle	Tourette Syndrome Tics, Obsessive-compulsive disorder Basal ganglia Miranda C,Marcelo Menéndez G,Pedro David G,Perla Troncoso Sch,Mónica Hernández Ch,Marta Chaná C,Pedro Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
description	Background: Tourettes syndrome is a childhood-onset hereditary neurobehavioural disorder believed to occur without geographical restrictions. Although there have been reports of this disorder worldwide just a few are from Latin America. Aim: To report a preliminary experience with a series of 70 patients and to review recent advances in this disorder. Patients and Method: We reviewed patients seen in pediatric and adult neurological clinics in Santiago, Chile, all of whom fulfilled clinical diagnostic criteria for Tourette Syndrome. Results: Seventy patients were studied, 54 males (77.1%) and 16 females (22.8%), their mean age at first evaluation was 13.6 years (range 2-46). The mean age of onset of symptoms was 6.4 (range 2-20), the mean time of follow-up was 3 years. Fifty-eight patients showed simple motor tics (blinking, facial grimacing, shoulder shrugging), whereas dystonic tics like head jerking were seen in 38 patients, torticollis in 6 and oculogyric movements in 2. Complex motor tics like jumping, antics, trunk bending and head shaking were present in 16 subjects. Vocal tics were predominantly of the simple type: sniffing, throat clearing, blowing, and whistling. Complex vocal tics were seen in 12 patients, five cases showed palilalia, 3 echolalia and only six displayed coprolalia (8.5%). Tics were of mild to moderate severity in most patients. Obsessive-compulsive disorder was observed in 22.8% and attention deficit and hyperactivity disorder were present in 35.7%. Forty-five patients (64.2%) had a first degree relative with tics, nine patients (12.8%) had a family history of obsessive-compulsive disorder. The current evidence involving desinhibition of cortico-striatum-thalamic-cortical neuronal circuits in the pathogenesis of this disorder is analyzed. Conclusion: Our report supports the recognized clinical homogeneity and genetical basis of Tourettes syndrome regardless of geographical region and ethnic origin.
author	Miranda C,Marcelo Menéndez G,Pedro David G,Perla Troncoso Sch,Mónica Hernández Ch,Marta Chaná C,Pedro
author_facet	Miranda C,Marcelo Menéndez G,Pedro David G,Perla Troncoso Sch,Mónica Hernández Ch,Marta Chaná C,Pedro
author_sort	Miranda C,Marcelo
title	Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
title_short	Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
title_full	Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
title_fullStr	Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
title_full_unstemmed	Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes
title_sort	enfermedad de los tics (síndrome de gilles de la tourette): características clínicas de 70 pacientes
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200010
work_keys_str_mv	AT mirandacmarcelo enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes AT menendezgpedro enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes AT davidgperla enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes AT troncososchmonica enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes AT hernandezchmarta enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes AT chanacpedro enfermedaddelosticssindromedegillesdelatourettecaracteristicasclinicasde70pacientes
_version_	1718435895679385600

Enfermedad de los tics (síndrome de Gilles de la Tourette): características clínicas de 70 pacientes

Ejemplares similares