Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico

We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal &am...

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Autores principales: Soza R,Alejandro, Riquelme P,Fernando, Alvarez L,Manuel, Duarte G,Ignacio, Glasinovic R,Juan Carlos, Arrese J,Marco
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 1999
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200011
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spelling oai:scielo:S0034-988719990012000112000-04-05Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínicoSoza R,AlejandroRiquelme P,FernandoAlvarez L,ManuelDuarte G,IgnacioGlasinovic R,Juan CarlosArrese J,Marco Amoxicillin Cholestasis, intrahepatic Clavulanic acids Hepatitis, toxic Ursodeoxycholic acid We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.12 19991999-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200011es10.4067/S0034-98871999001200011
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Amoxicillin
Cholestasis, intrahepatic
Clavulanic acids
Hepatitis, toxic
Ursodeoxycholic acid
spellingShingle Amoxicillin
Cholestasis, intrahepatic
Clavulanic acids
Hepatitis, toxic
Ursodeoxycholic acid
Soza R,Alejandro
Riquelme P,Fernando
Alvarez L,Manuel
Duarte G,Ignacio
Glasinovic R,Juan Carlos
Arrese J,Marco
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
description We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis.
author Soza R,Alejandro
Riquelme P,Fernando
Alvarez L,Manuel
Duarte G,Ignacio
Glasinovic R,Juan Carlos
Arrese J,Marco
author_facet Soza R,Alejandro
Riquelme P,Fernando
Alvarez L,Manuel
Duarte G,Ignacio
Glasinovic R,Juan Carlos
Arrese J,Marco
author_sort Soza R,Alejandro
title Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
title_short Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
title_full Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
title_fullStr Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
title_full_unstemmed Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
title_sort hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
publisher Sociedad Médica de Santiago
publishDate 1999
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200011
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AT alvarezlmanuel hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico
AT duartegignacio hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico
AT glasinovicrjuancarlos hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico
AT arresejmarco hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico
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