Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico
We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal &am...
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Sociedad Médica de Santiago
1999
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oai:scielo:S0034-988719990012000112000-04-05Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínicoSoza R,AlejandroRiquelme P,FernandoAlvarez L,ManuelDuarte G,IgnacioGlasinovic R,Juan CarlosArrese J,Marco Amoxicillin Cholestasis, intrahepatic Clavulanic acids Hepatitis, toxic Ursodeoxycholic acid We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.12 19991999-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200011es10.4067/S0034-98871999001200011 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
Spanish / Castilian |
topic |
Amoxicillin Cholestasis, intrahepatic Clavulanic acids Hepatitis, toxic Ursodeoxycholic acid |
spellingShingle |
Amoxicillin Cholestasis, intrahepatic Clavulanic acids Hepatitis, toxic Ursodeoxycholic acid Soza R,Alejandro Riquelme P,Fernando Alvarez L,Manuel Duarte G,Ignacio Glasinovic R,Juan Carlos Arrese J,Marco Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
description |
We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis. |
author |
Soza R,Alejandro Riquelme P,Fernando Alvarez L,Manuel Duarte G,Ignacio Glasinovic R,Juan Carlos Arrese J,Marco |
author_facet |
Soza R,Alejandro Riquelme P,Fernando Alvarez L,Manuel Duarte G,Ignacio Glasinovic R,Juan Carlos Arrese J,Marco |
author_sort |
Soza R,Alejandro |
title |
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
title_short |
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
title_full |
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
title_fullStr |
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
title_full_unstemmed |
Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
title_sort |
hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico |
publisher |
Sociedad Médica de Santiago |
publishDate |
1999 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200011 |
work_keys_str_mv |
AT sozaralejandro hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico AT riquelmepfernando hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico AT alvarezlmanuel hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico AT duartegignacio hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico AT glasinovicrjuancarlos hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico AT arresejmarco hepatotoxicidadporamoxicilinaacidoclavulanicocasoclinico |
_version_ |
1718435895890149376 |