Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino

The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor su...

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Autores principales:	Chuaqui F,Rodrigo, Cuello F,Mauricio, Emmert-Buck,Michael
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 1999
Materias:	Cervix neoplasma Genes, suppressor, tumor Genetic techniques Oncogenes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200014
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spelling	oai:scielo:S0034-988719990012000142000-04-05Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterinoChuaqui F,RodrigoCuello F,MauricioEmmert-Buck,Michael Cervix neoplasma Genes, suppressor, tumor Genetic techniques Oncogenes The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in this neoplasia. Genetic deletions affecting tumor suppressor genes are the most common mechanism of inactivation of these genes. Studies using conventional molecular techniques such as restriction fragment length polymorphism (RFLP) and Southern Blot showed low frequency of deletions in cervical carcinomas. Detection of deletions by using RFLP and Southern Blot presents several disadvantages, the most important being the difficulty in analyzing pure tumor cells. More sensitive approaches include tissue microdissection and PCR analysis of microsatellites. Using these approaches, it has been shown that genetic deletions are, in fact, frequent events in cervical cancers, being detected in up to 95% of the cases. Multiple genetic loci are involved, including chromosomes 3p, 5p, 6p and 11q. Deletions are detected even in precursor lesions (cervical intraepithelial neoplasia, CIN). Some deletions have been correlated with prognostic parameters, such as stage, depth of invasion, and vascular space involvement. It is concluded that cervical carcinogenesis, like in other tumors, is a multistep process, characterized by the accumulation of events including activation of oncogenes, as well as inactivation of tumor suppressor genes.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.127 n.12 19991999-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200014es10.4067/S0034-98871999001200014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cervix neoplasma Genes, suppressor, tumor Genetic techniques Oncogenes
spellingShingle	Cervix neoplasma Genes, suppressor, tumor Genetic techniques Oncogenes Chuaqui F,Rodrigo Cuello F,Mauricio Emmert-Buck,Michael Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
description	The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in this neoplasia. Genetic deletions affecting tumor suppressor genes are the most common mechanism of inactivation of these genes. Studies using conventional molecular techniques such as restriction fragment length polymorphism (RFLP) and Southern Blot showed low frequency of deletions in cervical carcinomas. Detection of deletions by using RFLP and Southern Blot presents several disadvantages, the most important being the difficulty in analyzing pure tumor cells. More sensitive approaches include tissue microdissection and PCR analysis of microsatellites. Using these approaches, it has been shown that genetic deletions are, in fact, frequent events in cervical cancers, being detected in up to 95% of the cases. Multiple genetic loci are involved, including chromosomes 3p, 5p, 6p and 11q. Deletions are detected even in precursor lesions (cervical intraepithelial neoplasia, CIN). Some deletions have been correlated with prognostic parameters, such as stage, depth of invasion, and vascular space involvement. It is concluded that cervical carcinogenesis, like in other tumors, is a multistep process, characterized by the accumulation of events including activation of oncogenes, as well as inactivation of tumor suppressor genes.
author	Chuaqui F,Rodrigo Cuello F,Mauricio Emmert-Buck,Michael
author_facet	Chuaqui F,Rodrigo Cuello F,Mauricio Emmert-Buck,Michael
author_sort	Chuaqui F,Rodrigo
title	Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
title_short	Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
title_full	Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
title_fullStr	Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
title_full_unstemmed	Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
title_sort	inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino
publisher	Sociedad Médica de Santiago
publishDate	1999
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001200014
work_keys_str_mv	AT chuaquifrodrigo inactivaciondegenessupresoresdetumoresenlacarcinogenesisdelcuellouterino AT cuellofmauricio inactivaciondegenessupresoresdetumoresenlacarcinogenesisdelcuellouterino AT emmertbuckmichael inactivaciondegenessupresoresdetumoresenlacarcinogenesisdelcuellouterino
_version_	1718435896470011904

Inactivación de genes supresores de tumores en la carcinogénesis del cuello uterino

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