Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica
Background: The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects. Aim: To assess the frequency of speA, speB and speC genes in Chilean Strep...
Guardado en:
Autores principales: | , , , , , , , , |
---|---|
Lenguaje: | Spanish / Castilian |
Publicado: |
Sociedad Médica de Santiago
2000
|
Materias: | |
Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000100004 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:scielo:S0034-98872000000100004 |
---|---|
record_format |
dspace |
spelling |
oai:scielo:S0034-988720000001000042000-05-25Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínicaUlloa F,María TeresaGiglio M,María SoledadPorte T,LorenaSanta Cruz A,AdrianaMcNab M,PaulFica C,AlbertoPinto C,María EugeniaKawaguchi G,KeykoCarmi K,Alejandra Exotoxins Gene frecuency Polymerase chain reaction Background: The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects. Aim: To assess the frequency of speA, speB and speC genes in Chilean Streptococcus pyogenes strains and their association with the invasiveness of infections. Material and methods: The genes for pyrogenic exotoxins SpeA, SpeB and SpeC were determined by polymerase chain reactions in 114 strains of group A Streptococcus pyogenes isolated from Chilean patients with invasive or non invasive infections. Results: The gene for SpeA was present in 30.7% of isolates, the gene for SpeB was present in 69.3% and the gen for SpeC in 44.7% of isolates. The gene for SpeA was present in 20 of 33 invasive infections and in 15 of 81 non invasive infections (p <0.0001). On the contrary, the gene for SpeC was present in 11 of 33 invasive infections and in 41 of 81 non invasive infections (p <0.05). The frequency of speB was similar in invasive and non invasive infections. Conclusions: There is a clear relationship between the presence of SpeA genes and the severity of infections caused by Streptococcus pyogenes. (Rev Méd Chile 2000; 128: 27-34)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.1 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000100004es10.4067/S0034-98872000000100004 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
Spanish / Castilian |
topic |
Exotoxins Gene frecuency Polymerase chain reaction |
spellingShingle |
Exotoxins Gene frecuency Polymerase chain reaction Ulloa F,María Teresa Giglio M,María Soledad Porte T,Lorena Santa Cruz A,Adriana McNab M,Paul Fica C,Alberto Pinto C,María Eugenia Kawaguchi G,Keyko Carmi K,Alejandra Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
description |
Background: The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects. Aim: To assess the frequency of speA, speB and speC genes in Chilean Streptococcus pyogenes strains and their association with the invasiveness of infections. Material and methods: The genes for pyrogenic exotoxins SpeA, SpeB and SpeC were determined by polymerase chain reactions in 114 strains of group A Streptococcus pyogenes isolated from Chilean patients with invasive or non invasive infections. Results: The gene for SpeA was present in 30.7% of isolates, the gene for SpeB was present in 69.3% and the gen for SpeC in 44.7% of isolates. The gene for SpeA was present in 20 of 33 invasive infections and in 15 of 81 non invasive infections (p <0.0001). On the contrary, the gene for SpeC was present in 11 of 33 invasive infections and in 41 of 81 non invasive infections (p <0.05). The frequency of speB was similar in invasive and non invasive infections. Conclusions: There is a clear relationship between the presence of SpeA genes and the severity of infections caused by Streptococcus pyogenes. (Rev Méd Chile 2000; 128: 27-34) |
author |
Ulloa F,María Teresa Giglio M,María Soledad Porte T,Lorena Santa Cruz A,Adriana McNab M,Paul Fica C,Alberto Pinto C,María Eugenia Kawaguchi G,Keyko Carmi K,Alejandra |
author_facet |
Ulloa F,María Teresa Giglio M,María Soledad Porte T,Lorena Santa Cruz A,Adriana McNab M,Paul Fica C,Alberto Pinto C,María Eugenia Kawaguchi G,Keyko Carmi K,Alejandra |
author_sort |
Ulloa F,María Teresa |
title |
Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
title_short |
Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
title_full |
Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
title_fullStr |
Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
title_full_unstemmed |
Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica |
title_sort |
detección de los genes de las exotoxinas pirogénicas spea, speb y spec en cepas chilenas de streptococcus pyogenes y su asociación con la clínica |
publisher |
Sociedad Médica de Santiago |
publishDate |
2000 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000100004 |
work_keys_str_mv |
AT ulloafmariateresa detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT gigliommariasoledad detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT portetlorena detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT santacruzaadriana detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT mcnabmpaul detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT ficacalberto detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT pintocmariaeugenia detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT kawaguchigkeyko detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica AT carmikalejandra detecciondelosgenesdelasexotoxinaspirogenicasspeaspebyspecencepaschilenasdestreptococcuspyogenesysuasociacionconlaclinica |
_version_ |
1718435898573455360 |