Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral

Background: Many hospitalized patients with community acquired pneumoniae can be switched early in the course of therapy from intravenous to oral antibiotics, when there are subjective and objective indicators of improvement. This modality of treatment is called "switch therapy". Aim: To c...

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Autores principales:	Fernández V,Patricia, San Martín V.,Lucy
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Ceftriaxone Cephalosporins Pneumonia bacterial
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300003
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spelling	oai:scielo:S0034-988720000003000032000-06-20Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oralFernández V,PatriciaSan Martín V.,Lucy Ceftriaxone Cephalosporins Pneumonia bacterial Background: Many hospitalized patients with community acquired pneumoniae can be switched early in the course of therapy from intravenous to oral antibiotics, when there are subjective and objective indicators of improvement. This modality of treatment is called "switch therapy". Aim: To compare sequential therapy using an oral third generation cephalosporin, with conventional therapy using intravenous ceftriazone in community acquired pneumonia. Patients and methods: Forty patients admitted due to community acquired pneumonia, initially treated with ceftriazone 1 g/day iv and that showed clinical improvement after three days of therapy, were studied. They were randomly assigned to continue intravenous therapy with ceftriazone for a total of 10 days or switched to ceftibuten 400 mg od for seven days. Results: Twenty one patients continued iv treatment and 19 were switched to ceftibuten. There were no differences between both groups in terms of clinical cure, radiological improvement or normalisation of white blood cell count. Conclusions: Patients with community acquired pneumonia that have a good initial response to intravenous antimicrobials, can be safely switched to oral therapy. This therapy will shorten hospital stay and thereby treatment costsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.3 20002000-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300003es10.4067/S0034-98872000000300003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ceftriaxone Cephalosporins Pneumonia bacterial
spellingShingle	Ceftriaxone Cephalosporins Pneumonia bacterial Fernández V,Patricia San Martín V.,Lucy Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
description	Background: Many hospitalized patients with community acquired pneumoniae can be switched early in the course of therapy from intravenous to oral antibiotics, when there are subjective and objective indicators of improvement. This modality of treatment is called "switch therapy". Aim: To compare sequential therapy using an oral third generation cephalosporin, with conventional therapy using intravenous ceftriazone in community acquired pneumonia. Patients and methods: Forty patients admitted due to community acquired pneumonia, initially treated with ceftriazone 1 g/day iv and that showed clinical improvement after three days of therapy, were studied. They were randomly assigned to continue intravenous therapy with ceftriazone for a total of 10 days or switched to ceftibuten 400 mg od for seven days. Results: Twenty one patients continued iv treatment and 19 were switched to ceftibuten. There were no differences between both groups in terms of clinical cure, radiological improvement or normalisation of white blood cell count. Conclusions: Patients with community acquired pneumonia that have a good initial response to intravenous antimicrobials, can be safely switched to oral therapy. This therapy will shorten hospital stay and thereby treatment costs
author	Fernández V,Patricia San Martín V.,Lucy
author_facet	Fernández V,Patricia San Martín V.,Lucy
author_sort	Fernández V,Patricia
title	Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
title_short	Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
title_full	Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
title_fullStr	Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
title_full_unstemmed	Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral
title_sort	neumonía adquirida en la comunidad: terapia secuencial de cefalosporina intravenosa a cefalosporina oral
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300003
work_keys_str_mv	AT fernandezvpatricia neumoniaadquiridaenlacomunidadterapiasecuencialdecefalosporinaintravenosaacefalosporinaoral AT sanmartinvlucy neumoniaadquiridaenlacomunidadterapiasecuencialdecefalosporinaintravenosaacefalosporinaoral
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Neumonía adquirida en la comunidad: Terapia secuencial de cefalosporina intravenosa a cefalosporina oral

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