Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis

Background: Anti liver kidney microsome antibodies (LKM-1) have been recently incorporated to the study and classification of chronic autoimmune hepatitis (HC-A1). The presence of anti LKM-1 antibodies and essential cryoglobulinemia is frequent in virus C associated chronic hepatitis (HC-VC). Aim: T...

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Autores principales:	Jirón V,M. Isabel, Ardiles S,Adriana, Parra B,M Adriana, Orellana V,Juana
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Cryoglobulinemia Hepatitis autoimmune Hepatitis C chronic Liver cirrhosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300004
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spelling	oai:scielo:S0034-988720000003000042000-06-20Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitisJirón V,M. IsabelArdiles S,AdrianaParra B,M AdrianaOrellana V,Juana Cryoglobulinemia Hepatitis autoimmune Hepatitis C chronic Liver cirrhosis Background: Anti liver kidney microsome antibodies (LKM-1) have been recently incorporated to the study and classification of chronic autoimmune hepatitis (HC-A1). The presence of anti LKM-1 antibodies and essential cryoglobulinemia is frequent in virus C associated chronic hepatitis (HC-VC). Aim: To study the frequency of anti LKM-1 antibodies and cryoglobulin levels in patients with HC-AI, HC-VC and cryptogenic cirrhosis. Patients and methods: Forty two patients were studied. Nineteen adult women with classic HC-AI with positive antinuclear or anti smooth muscle antibodies. Five patients of less than 20 years old with HC-AI and negative antinuclear and anti smooth muscle antibodies. Ten adult women with cryptogenic cirrhosis, 4 women and 4 men with HC-VC. Serum samples were obtained at 37°C. Antinuclear, anti smooth muscle and anti LKM-1 antibodies were measured by indirect immunofluorescence using Hep-2 cells and rat tissue slices as substrates. Cryoglobulins were determined by the traditional method and cryocrit. Results: All studied patients were anti LKM-1 negative. All had significant circulating cryoglobulin levels. Conclusions: In this sample of patients with HC-AI or HC-VC, anti LKM-1 antibodies were not detected but all had cryoglobulinemiainfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.3 20002000-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300004es10.4067/S0034-98872000000300004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cryoglobulinemia Hepatitis autoimmune Hepatitis C chronic Liver cirrhosis
spellingShingle	Cryoglobulinemia Hepatitis autoimmune Hepatitis C chronic Liver cirrhosis Jirón V,M. Isabel Ardiles S,Adriana Parra B,M Adriana Orellana V,Juana Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
description	Background: Anti liver kidney microsome antibodies (LKM-1) have been recently incorporated to the study and classification of chronic autoimmune hepatitis (HC-A1). The presence of anti LKM-1 antibodies and essential cryoglobulinemia is frequent in virus C associated chronic hepatitis (HC-VC). Aim: To study the frequency of anti LKM-1 antibodies and cryoglobulin levels in patients with HC-AI, HC-VC and cryptogenic cirrhosis. Patients and methods: Forty two patients were studied. Nineteen adult women with classic HC-AI with positive antinuclear or anti smooth muscle antibodies. Five patients of less than 20 years old with HC-AI and negative antinuclear and anti smooth muscle antibodies. Ten adult women with cryptogenic cirrhosis, 4 women and 4 men with HC-VC. Serum samples were obtained at 37°C. Antinuclear, anti smooth muscle and anti LKM-1 antibodies were measured by indirect immunofluorescence using Hep-2 cells and rat tissue slices as substrates. Cryoglobulins were determined by the traditional method and cryocrit. Results: All studied patients were anti LKM-1 negative. All had significant circulating cryoglobulin levels. Conclusions: In this sample of patients with HC-AI or HC-VC, anti LKM-1 antibodies were not detected but all had cryoglobulinemia
author	Jirón V,M. Isabel Ardiles S,Adriana Parra B,M Adriana Orellana V,Juana
author_facet	Jirón V,M. Isabel Ardiles S,Adriana Parra B,M Adriana Orellana V,Juana
author_sort	Jirón V,M. Isabel
title	Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
title_short	Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
title_full	Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
title_fullStr	Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
title_full_unstemmed	Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis
title_sort	anticuerpos anti lkm-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus c de la hepatitis
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300004
work_keys_str_mv	AT jironvmisabel anticuerposantilkm1ycrioglobulinemiaenhepatitiscronicaautoinmuneyporviruscdelahepatitis AT ardilessadriana anticuerposantilkm1ycrioglobulinemiaenhepatitiscronicaautoinmuneyporviruscdelahepatitis AT parrabmadriana anticuerposantilkm1ycrioglobulinemiaenhepatitiscronicaautoinmuneyporviruscdelahepatitis AT orellanavjuana anticuerposantilkm1ycrioglobulinemiaenhepatitiscronicaautoinmuneyporviruscdelahepatitis
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Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis

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