Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos

Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosi...

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Autores principales:	Alfaro L,Jorge, Von Mühlenbrock S,Ricardo, Burgos S,Nelson, Valdés R,Enrique, Gana A,Clara, Conte L,Guillermo, Araos H,Daniel, Plate B,Ludwig
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Abortion,induced Leucovorin Methotrexate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300010
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spelling	oai:scielo:S0034-988720000003000102000-06-20Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casosAlfaro L,JorgeVon Mühlenbrock S,RicardoBurgos S,NelsonValdés R,EnriqueGana A,ClaraConte L,GuillermoAraos H,DanielPlate B,Ludwig Abortion,induced Leucovorin Methotrexate Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be startedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.3 20002000-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300010es10.4067/S0034-98872000000300010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Abortion,induced Leucovorin Methotrexate
spellingShingle	Abortion,induced Leucovorin Methotrexate Alfaro L,Jorge Von Mühlenbrock S,Ricardo Burgos S,Nelson Valdés R,Enrique Gana A,Clara Conte L,Guillermo Araos H,Daniel Plate B,Ludwig Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
description	Acute intoxication with methotrexate, used as an abortive, has not been described in Chile. We report two female patients, aged 15 and 24 years old, who presented with mucositis, erythrodermia, pancytopenia, and elevation of hepatic enzymes. Plasma methotrexate levels confirmed the clinical diagnosis and both patients were treated with high leucovorin doses and management of associated complications. In one patient, pregnancy continued, giving birth to a newborn with cranial, face and limb malformations. The second patient had a late rescue with leucovorin and was discharged with a persistent sensory motor neuropathy. Considering the severity of complications and that patients may deny its use, when there is reasonable clinical suspicion of methotrexate intoxication, leucovorin treatment should be started
author	Alfaro L,Jorge Von Mühlenbrock S,Ricardo Burgos S,Nelson Valdés R,Enrique Gana A,Clara Conte L,Guillermo Araos H,Daniel Plate B,Ludwig
author_facet	Alfaro L,Jorge Von Mühlenbrock S,Ricardo Burgos S,Nelson Valdés R,Enrique Gana A,Clara Conte L,Guillermo Araos H,Daniel Plate B,Ludwig
author_sort	Alfaro L,Jorge
title	Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
title_short	Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
title_full	Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
title_fullStr	Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
title_full_unstemmed	Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
title_sort	intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300010
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Intoxicación aguda con metotrexato usado con fines abortivos: descripción de 2 casos

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