Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio

Background: Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate. Aim: To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone t...

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Autores principales:	Campusano M,Claudia, López M,José M., Campino J,Carmen, Cárdenas G,Isabel, Rojas O,Auristela
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Bone diseases, endocrine Calcitonin Hydroxyproline Osteoporosis age-related
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400004
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spelling	oai:scielo:S0034-988720000004000042005-11-29Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambioCampusano M,ClaudiaLópez M,José M.Campino J,CarmenCárdenas G,IsabelRojas O,Auristela Bone diseases, endocrine Calcitonin Hydroxyproline Osteoporosis age-related Background: Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate. Aim: To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover. Patients and methods: Forty one healthy women aged 56 ± 6 years old, with a mean lapse after menopause of 7.6 ± 6.5 years and with a high bone turnover rate, evidenced by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 ± 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days. Results: Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period. Conclusions: Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women. (Rev Méd Chile 2000; 128: 387-91)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.4 20002000-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400004es10.4067/S0034-98872000000400004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bone diseases, endocrine Calcitonin Hydroxyproline Osteoporosis age-related
spellingShingle	Bone diseases, endocrine Calcitonin Hydroxyproline Osteoporosis age-related Campusano M,Claudia López M,José M. Campino J,Carmen Cárdenas G,Isabel Rojas O,Auristela Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
description	Background: Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate. Aim: To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover. Patients and methods: Forty one healthy women aged 56 ± 6 years old, with a mean lapse after menopause of 7.6 ± 6.5 years and with a high bone turnover rate, evidenced by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 ± 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days. Results: Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period. Conclusions: Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women. (Rev Méd Chile 2000; 128: 387-91)
author	Campusano M,Claudia López M,José M. Campino J,Carmen Cárdenas G,Isabel Rojas O,Auristela
author_facet	Campusano M,Claudia López M,José M. Campino J,Carmen Cárdenas G,Isabel Rojas O,Auristela
author_sort	Campusano M,Claudia
title	Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
title_short	Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
title_full	Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
title_fullStr	Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
title_full_unstemmed	Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
title_sort	efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400004
work_keys_str_mv	AT campusanomclaudia efectodedosisbajasdecalcitoninasobrelaremodelacionoseaenmujerespostmenopausicasconaltorecambio AT lopezmjosem efectodedosisbajasdecalcitoninasobrelaremodelacionoseaenmujerespostmenopausicasconaltorecambio AT campinojcarmen efectodedosisbajasdecalcitoninasobrelaremodelacionoseaenmujerespostmenopausicasconaltorecambio AT cardenasgisabel efectodedosisbajasdecalcitoninasobrelaremodelacionoseaenmujerespostmenopausicasconaltorecambio AT rojasoauristela efectodedosisbajasdecalcitoninasobrelaremodelacionoseaenmujerespostmenopausicasconaltorecambio
_version_	1718435912786903040

Efecto de dosis bajas de calcitonina sobre la remodelación ósea en mujeres postmenopáusicas con alto recambio

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