Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus

PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (...

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Autores principales:	Uauy D,Ricardo, Martínez A,Jessica I., Rojas B,Cecilia V.
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Diabetes mellitus Lipid peroxidation Obesity Obesity in diabetes Peroxisome proliferators
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400012
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spelling	oai:scielo:S0034-988720000004000122005-11-29Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitusUauy D,RicardoMartínez A,Jessica I.Rojas B,Cecilia V. Diabetes mellitus Lipid peroxidation Obesity Obesity in diabetes Peroxisome proliferators PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPARg) and catabolic (PPARa) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance. (Rev Méd Chile 2000; 128: 437-46).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.4 20002000-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400012es10.4067/S0034-98872000000400012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus Lipid peroxidation Obesity Obesity in diabetes Peroxisome proliferators
spellingShingle	Diabetes mellitus Lipid peroxidation Obesity Obesity in diabetes Peroxisome proliferators Uauy D,Ricardo Martínez A,Jessica I. Rojas B,Cecilia V. Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
description	PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPARg) and catabolic (PPARa) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance. (Rev Méd Chile 2000; 128: 437-46).
author	Uauy D,Ricardo Martínez A,Jessica I. Rojas B,Cecilia V.
author_facet	Uauy D,Ricardo Martínez A,Jessica I. Rojas B,Cecilia V.
author_sort	Uauy D,Ricardo
title	Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
title_short	Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
title_full	Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
title_fullStr	Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
title_full_unstemmed	Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
title_sort	nutrición molecular, papel del sistema ppar en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (ppar). their relatioship to obesity and diabetes mellitus
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000400012
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Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus

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