Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas

Background: Radio-iodine is a definite therapy for Graves disease hyperthyroidism. However, the optimal dosage is still debatable. Aim: To assess the effects of different radioiodine doses on thyroid function and complications in patients with hyperthyroidism. Material and methods: A retrospective a...

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Autores principales:	Pineda B,Pedro, Michelsen D,Harold, Rivera C,Marcela, Lillo G,Ricardo, Massardo V,Teresa, Araya Q,Verónica, Sierralta C,Paulina, Oviedo G,Sofía, Liberman G,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Hyperthyroidism Iodine radioisotopes Radiochemestry Radiation dosages, ionizing
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500007
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spelling	oai:scielo:S0034-988720000005000072004-06-22Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadasPineda B,PedroMichelsen D,HaroldRivera C,MarcelaLillo G,RicardoMassardo V,TeresaAraya Q,VerónicaSierralta C,PaulinaOviedo G,SofíaLiberman G,Claudio Hyperthyroidism Iodine radioisotopes Radiochemestry Radiation dosages, ionizing Background: Radio-iodine is a definite therapy for Graves disease hyperthyroidism. However, the optimal dosage is still debatable. Aim: To assess the effects of different radioiodine doses on thyroid function and complications in patients with hyperthyroidism. Material and methods: A retrospective analysis of 139 patients with hyperthyroidism, treated with ratioiodine between 1988 and 1998. Radio iodine dose used was classified as low (<10 mCi), intermediate (10-14.9 mCi) or high ( > or = 15 mCi). Results: Thirty five patients were treated with low doses, 33 with intermediate doses and 71 with high doses. There were no differences between these patients in age, disease severity, frequency of post treatment euthyroidism or complications. Patients treated with low doses had a higher frequency of persistent hyperthyroidism than patients treated with high doses (25.7 and 4.2% respectively, p<0,001). Likewise, the frequency of subsequent hypothyroidism was 60% in patients treated with low doses and 84.5% of those with high doses, in whom it also appeared earlier. Associated complications were clinically irrelevant. In seven patients, Graves ophtalmopathy progressed after treatment, but this progression was not associated with the dose used. Conclusions: Radio iodine in high doses is useful, safe and effective for the treatment of Graves hyperthyroidism. (Rev Méd Chile 2000; 128: 499-507).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.5 20002000-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500007es10.4067/S0034-98872000000500007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hyperthyroidism Iodine radioisotopes Radiochemestry Radiation dosages, ionizing
spellingShingle	Hyperthyroidism Iodine radioisotopes Radiochemestry Radiation dosages, ionizing Pineda B,Pedro Michelsen D,Harold Rivera C,Marcela Lillo G,Ricardo Massardo V,Teresa Araya Q,Verónica Sierralta C,Paulina Oviedo G,Sofía Liberman G,Claudio Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
description	Background: Radio-iodine is a definite therapy for Graves disease hyperthyroidism. However, the optimal dosage is still debatable. Aim: To assess the effects of different radioiodine doses on thyroid function and complications in patients with hyperthyroidism. Material and methods: A retrospective analysis of 139 patients with hyperthyroidism, treated with ratioiodine between 1988 and 1998. Radio iodine dose used was classified as low (<10 mCi), intermediate (10-14.9 mCi) or high ( > or = 15 mCi). Results: Thirty five patients were treated with low doses, 33 with intermediate doses and 71 with high doses. There were no differences between these patients in age, disease severity, frequency of post treatment euthyroidism or complications. Patients treated with low doses had a higher frequency of persistent hyperthyroidism than patients treated with high doses (25.7 and 4.2% respectively, p<0,001). Likewise, the frequency of subsequent hypothyroidism was 60% in patients treated with low doses and 84.5% of those with high doses, in whom it also appeared earlier. Associated complications were clinically irrelevant. In seven patients, Graves ophtalmopathy progressed after treatment, but this progression was not associated with the dose used. Conclusions: Radio iodine in high doses is useful, safe and effective for the treatment of Graves hyperthyroidism. (Rev Méd Chile 2000; 128: 499-507).
author	Pineda B,Pedro Michelsen D,Harold Rivera C,Marcela Lillo G,Ricardo Massardo V,Teresa Araya Q,Verónica Sierralta C,Paulina Oviedo G,Sofía Liberman G,Claudio
author_facet	Pineda B,Pedro Michelsen D,Harold Rivera C,Marcela Lillo G,Ricardo Massardo V,Teresa Araya Q,Verónica Sierralta C,Paulina Oviedo G,Sofía Liberman G,Claudio
author_sort	Pineda B,Pedro
title	Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
title_short	Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
title_full	Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
title_fullStr	Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
title_full_unstemmed	Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
title_sort	tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500007
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Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas

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