Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori

Background: the high cost and complexity of therapeutic schemes for the eradication of Helicobacter pylori has stimulated the search of simpler and cheaper treatment options. Aim: To evaluate the efficacy of 3 days of azithromycin 500 mg od, 7 days of amoxycilin 750 mg tid and omeprazole, 20 (Group...

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Autores principales:	Flores O,Sergio, Opazo S,Hector, Valderrama T,Danilo, Aguilera B,Renato, Marchese P,Annabella, Valderrama T.,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Amoxycilin Azithromycin Helycobacter pylori Omeprazole
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500008
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spelling	oai:scielo:S0034-988720000005000082004-06-22Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pyloriFlores O,SergioOpazo S,HectorValderrama T,DaniloAguilera B,RenatoMarchese P,AnnabellaValderrama T.,Sergio Amoxycilin Azithromycin Helycobacter pylori Omeprazole Background: the high cost and complexity of therapeutic schemes for the eradication of Helicobacter pylori has stimulated the search of simpler and cheaper treatment options. Aim: To evaluate the efficacy of 3 days of azithromycin 500 mg od, 7 days of amoxycilin 750 mg tid and omeprazole, 20 (Group A) or 40 mg (Group B) on randomization, as a treatment for Helicobacter pylori infection in patients with endoscopically diagnosed peptic ulcer. Methods: H. pylori status of peptic ulcer patients was pathologically confirmed by the examination of five gastric biopsies using the Giemsa stain and by rapid urease testing in two gastric biopsies. H. pylori status was reassessed not less than 28 days after completing treatment. Adverse events and compliance were evaluated. Results: Fifty four patients (29 men, 25 women, mean age 48 years) were enrolled, 28 in Group A and 27 in Group B. Per protocol the infection was cured in 58,8% of patients (30/51; 95% CI: 45-73%). On an intention to treat basis, H pylori infection was cured in 55%. Minor side effects including diarrhea and nausea were reported by 32% of patients. Ninety five per cent of patients consumed more than 95% of prescribed medications. H. pylori was successfully erradicated in 61% of group A and 57% of group B patients (p= NS). Conclusion: Short term therapy with azithromycin was poorly effective in curing H. pylori infection. The compliance was excellent. Increasing Omeprazole from 20 to 40 mg/day did not improve treatment effectiveness. (Rev Méd Chile 2000; 128: 509-12)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.5 20002000-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500008es10.4067/S0034-98872000000500008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Amoxycilin Azithromycin Helycobacter pylori Omeprazole
spellingShingle	Amoxycilin Azithromycin Helycobacter pylori Omeprazole Flores O,Sergio Opazo S,Hector Valderrama T,Danilo Aguilera B,Renato Marchese P,Annabella Valderrama T.,Sergio Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
description	Background: the high cost and complexity of therapeutic schemes for the eradication of Helicobacter pylori has stimulated the search of simpler and cheaper treatment options. Aim: To evaluate the efficacy of 3 days of azithromycin 500 mg od, 7 days of amoxycilin 750 mg tid and omeprazole, 20 (Group A) or 40 mg (Group B) on randomization, as a treatment for Helicobacter pylori infection in patients with endoscopically diagnosed peptic ulcer. Methods: H. pylori status of peptic ulcer patients was pathologically confirmed by the examination of five gastric biopsies using the Giemsa stain and by rapid urease testing in two gastric biopsies. H. pylori status was reassessed not less than 28 days after completing treatment. Adverse events and compliance were evaluated. Results: Fifty four patients (29 men, 25 women, mean age 48 years) were enrolled, 28 in Group A and 27 in Group B. Per protocol the infection was cured in 58,8% of patients (30/51; 95% CI: 45-73%). On an intention to treat basis, H pylori infection was cured in 55%. Minor side effects including diarrhea and nausea were reported by 32% of patients. Ninety five per cent of patients consumed more than 95% of prescribed medications. H. pylori was successfully erradicated in 61% of group A and 57% of group B patients (p= NS). Conclusion: Short term therapy with azithromycin was poorly effective in curing H. pylori infection. The compliance was excellent. Increasing Omeprazole from 20 to 40 mg/day did not improve treatment effectiveness. (Rev Méd Chile 2000; 128: 509-12)
author	Flores O,Sergio Opazo S,Hector Valderrama T,Danilo Aguilera B,Renato Marchese P,Annabella Valderrama T.,Sergio
author_facet	Flores O,Sergio Opazo S,Hector Valderrama T,Danilo Aguilera B,Renato Marchese P,Annabella Valderrama T.,Sergio
author_sort	Flores O,Sergio
title	Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
title_short	Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
title_full	Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
title_fullStr	Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
title_full_unstemmed	Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori
title_sort	terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del helicobacter pylori
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500008
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Terapia triple de corto tiempo con azitromicina, amoxicilina y omeprazo para la erradicación del Helicobacter pylori

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