Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999

Background: Anorectal atresia is a relatively frequent malformation in the newborn. According to the Latin American Collaborative Study for Congenital Malformations (ECLAMC), its frequency is 4.1 per 10,000 born alive. Aim: To determine the frequency of anorectal malformations at birth, and compare...

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Autores principales:	Nazer H,Julio, Hubner G,María Eugenia, Valenzuela F,Pablo, Cifuentes O,Lucía
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Abnormalities Gnes recessive Rectal diseases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500010
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spelling	oai:scielo:S0034-988720000005000102004-06-22Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999Nazer H,JulioHubner G,María EugeniaValenzuela F,PabloCifuentes O,Lucía Abnormalities Gnes recessive Rectal diseases Background: Anorectal atresia is a relatively frequent malformation in the newborn. According to the Latin American Collaborative Study for Congenital Malformations (ECLAMC), its frequency is 4.1 per 10,000 born alive. Aim: To determine the frequency of anorectal malformations at birth, and compare the figures with those of other maternity hospitals in Chile participating in ECLAMC, with the figures of the whole ECLAMC and with figures from other worldwide monitoring systems. Patients and methods: All births occurred in the University of Chile Clinical Hospital between January 1979 and August 1999, were reviewed. Results: During the study period, 70,242 children were born, 4,486 had a malformation and 54 had an anorectal malformation (7.7 per 10,000 born alive). Fifty nine percent had other associated malformations (of the urinary tract in 42.5%, skeletal in 26% and cardiovascular in 18.5%). Five stillborn babies had other severe malformations. Twenty one children had a fistula. Forty three % were male, 39% female and 18% had ambiguous sex. When compared with normal controls, malformed newborns had a lower birth weight, lower gestational age and a higher mean maternal age, a higher frequency of metrorrhagia during the first trimester of pregnancy, a higher number of siblings with malformations and a higher degree of consanguinity among parents. Conclusions: The participation of recessive genes in the etiology of anorectal malformations is suggested. (Rev Méd Chile 2000; 128: 519-25)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.5 20002000-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500010es10.4067/S0034-98872000000500010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Abnormalities Gnes recessive Rectal diseases
spellingShingle	Abnormalities Gnes recessive Rectal diseases Nazer H,Julio Hubner G,María Eugenia Valenzuela F,Pablo Cifuentes O,Lucía Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
description	Background: Anorectal atresia is a relatively frequent malformation in the newborn. According to the Latin American Collaborative Study for Congenital Malformations (ECLAMC), its frequency is 4.1 per 10,000 born alive. Aim: To determine the frequency of anorectal malformations at birth, and compare the figures with those of other maternity hospitals in Chile participating in ECLAMC, with the figures of the whole ECLAMC and with figures from other worldwide monitoring systems. Patients and methods: All births occurred in the University of Chile Clinical Hospital between January 1979 and August 1999, were reviewed. Results: During the study period, 70,242 children were born, 4,486 had a malformation and 54 had an anorectal malformation (7.7 per 10,000 born alive). Fifty nine percent had other associated malformations (of the urinary tract in 42.5%, skeletal in 26% and cardiovascular in 18.5%). Five stillborn babies had other severe malformations. Twenty one children had a fistula. Forty three % were male, 39% female and 18% had ambiguous sex. When compared with normal controls, malformed newborns had a lower birth weight, lower gestational age and a higher mean maternal age, a higher frequency of metrorrhagia during the first trimester of pregnancy, a higher number of siblings with malformations and a higher degree of consanguinity among parents. Conclusions: The participation of recessive genes in the etiology of anorectal malformations is suggested. (Rev Méd Chile 2000; 128: 519-25)
author	Nazer H,Julio Hubner G,María Eugenia Valenzuela F,Pablo Cifuentes O,Lucía
author_facet	Nazer H,Julio Hubner G,María Eugenia Valenzuela F,Pablo Cifuentes O,Lucía
author_sort	Nazer H,Julio
title	Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
title_short	Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
title_full	Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
title_fullStr	Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
title_full_unstemmed	Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999
title_sort	malformaciones congénitas anorrectales y sus asociaciones preferentes. experiencia del hospital clínico de la universidad de chile. período 1979-1999
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500010
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Malformaciones congénitas anorrectales y sus asociaciones preferentes. Experiencia del Hospital Clínico de la Universidad de Chile. Período 1979-1999

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