Tumorogénesis y proteína mdm2

Tumorogenesis is associated with several events by which a normal cell transforms itself into a tumour cell with an increased proliferation rate. One of the most important research initiatives in this area is the characterization of the molecular mechanisms involved in tumorogenesis and cancer. Onco...

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Autores principales:	Flores P,Carlos, Sobrevia L,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2000
Materias:	Gene amplification Gene expression regulation Mdm2 Oncogenes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500014
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spelling	oai:scielo:S0034-988720000005000142004-06-22Tumorogénesis y proteína mdm2Flores P,CarlosSobrevia L,Luis Gene amplification Gene expression regulation Mdm2 Oncogenes Tumorogenesis is associated with several events by which a normal cell transforms itself into a tumour cell with an increased proliferation rate. One of the most important research initiatives in this area is the characterization of the molecular mechanisms involved in tumorogenesis and cancer. Oncogenes and tumour suppressor genes are directly involved in the cell cycle, differentiation, and apoptosis. The cellular oncogene MDM2 seems to be abnormally elevated in several human tumours, specially in sarcomas. The MDM2 gene product, mdm2 protein, pS3 and retinoblastoma (Rb) proteins, play crucial roles in the control of the cell cycle. The molecular interactions between mdm2, pS3 and Rb in cancer, are associated with a loss of control in the G1 phase of the cell cycle leading to uncontrolled cell proliferation. Studies by gene amplification appear to show an incomplete picture of mdm2 protein levels in tumour cells. The simultaneous determination of mdm2 protein and mRNA levels seems to give a more accurate interpretation of the abnormal function of the mdm2 protein. Thus, in addition to gene amplification, different mechanisms by which mdm2 is overexpressed in cancer cells also play an important role in tumorogenesis. (Rev Méd Chile 2000; 128: 539-46)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.128 n.5 20002000-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500014es10.4067/S0034-98872000000500014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gene amplification Gene expression regulation Mdm2 Oncogenes
spellingShingle	Gene amplification Gene expression regulation Mdm2 Oncogenes Flores P,Carlos Sobrevia L,Luis Tumorogénesis y proteína mdm2
description	Tumorogenesis is associated with several events by which a normal cell transforms itself into a tumour cell with an increased proliferation rate. One of the most important research initiatives in this area is the characterization of the molecular mechanisms involved in tumorogenesis and cancer. Oncogenes and tumour suppressor genes are directly involved in the cell cycle, differentiation, and apoptosis. The cellular oncogene MDM2 seems to be abnormally elevated in several human tumours, specially in sarcomas. The MDM2 gene product, mdm2 protein, pS3 and retinoblastoma (Rb) proteins, play crucial roles in the control of the cell cycle. The molecular interactions between mdm2, pS3 and Rb in cancer, are associated with a loss of control in the G1 phase of the cell cycle leading to uncontrolled cell proliferation. Studies by gene amplification appear to show an incomplete picture of mdm2 protein levels in tumour cells. The simultaneous determination of mdm2 protein and mRNA levels seems to give a more accurate interpretation of the abnormal function of the mdm2 protein. Thus, in addition to gene amplification, different mechanisms by which mdm2 is overexpressed in cancer cells also play an important role in tumorogenesis. (Rev Méd Chile 2000; 128: 539-46)
author	Flores P,Carlos Sobrevia L,Luis
author_facet	Flores P,Carlos Sobrevia L,Luis
author_sort	Flores P,Carlos
title	Tumorogénesis y proteína mdm2
title_short	Tumorogénesis y proteína mdm2
title_full	Tumorogénesis y proteína mdm2
title_fullStr	Tumorogénesis y proteína mdm2
title_full_unstemmed	Tumorogénesis y proteína mdm2
title_sort	tumorogénesis y proteína mdm2
publisher	Sociedad Médica de Santiago
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500014
work_keys_str_mv	AT florespcarlos tumorogenesisyproteinamdm2 AT sobrevialluis tumorogenesisyproteinamdm2
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Tumorogénesis y proteína mdm2

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